3D-printed salt gives form to absorbable bone implants

How do you turn salt and magnesium (left) into a bone implant with regularly structured pores (right)? Researchers developed a method using a template of 3D-printed salt (center). (Credit: Laboratory of Metal Physics and Technology/Complex Materials /ETH Zurich)

3D-printed ‘salt templates’ have paved the way for new porous magnesium scaffolds for creating bone implants the body can absorb, researchers report.

For the treatment of complex bone fractures or even missing bone parts, surgeons typically deploy metal implants. In this context, biodegradable magnesium and its alloys are attractive alternatives to the traditional materials like bioinert titanium. Implants made of the light metal are advantageous because they can biodegrade in the body, which can absorb magnesium as a mineral nutrient, rendering a second surgery for implant removal unnecessary.

To promote rapid healing, the design of implants or their surfaces need to promote cellular adhesion or even growth into the implant. Researchers have therefore developed a new procedure for the manufacture of magnesium implants that contain numerous structurally ordered pores but still retain their mechanical stability.

The salt structure looks like stacked bars of salt, alternating in direction, while the magnesium implant shows uniform pores in a flat surface
The 3D-printed salt template (left, scale: 1 mm), into which magnesium melts. On the right, magnesium with regularly arranged pores remains. (Credit: Laboratory of Metal Physics and Technology/Complex Materials/ETH Zurich)

To create a porous structure the researchers first printed a three-dimensional salt template using a 3D printer. Because pure, standard table salt is not suitable for printing, they developed a gel-like salt paste for this purpose. The researchers can use the printing process to tailor the strut diameters and spacings of the salt template.

To gain sufficient mechanical strength, the researchers subsequently sintered the salt structure. During sintering, researchers heat the fine-grained materials significantly, while choosing a temperature that’s safely below the paste’s melting point to retain the structure of the workpiece.

The next step was to infiltrate the pores with magnesium melt. “The infiltrates obtained in this way are mechanically very stable and can be easily polished, turned, and shaped,” says Jörg Löffler, professor of metal physics and technology in the materials department at ETH Zurich. After mechanical shaping the researchers dissolved the salt, leaving a pure magnesium implant with numerous, regularly structured pores.

“The possibility to control the pore size, distribution, and orientation in the material is decisive for clinical success, because bone cells like to grow into these pores,” says Löffler. This process is key for the rapid integration of the implant in bone.

The new procedure for manufacturing these template structures from salt can also be applied to other materials besides magnesium. The researchers expect that the process could help tailor pore geometries in polymers, ceramics, and other light metals.

The idea of this new manufacturing procedure came out of the Master’s thesis of Nicole Kleger, now a doctoral student in the Complex Materials Group of André Studart, under whose direction researchers 3D printed the initial salt template. An ETH Zurich Excellence Scholarship & Opportunity stipend supported Kleger’s initial study. In her doctoral thesis project, Kleger is now developing the 3D-printing procedure further.

The research appears in Advanced Materials.

Source: ETH Zurich