Worse memory with age? It may just be ‘different’

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Aging memories may not be “worse,” just different, a new study suggests.

While it may not always be the first sign of aging, some faculties, including memory, do get worse as people age. But the process may not be as straightforward as it seems.

Zachariah Reagh, assistant professor of psychological and brain sciences at Washington University in St. Louis, looked at the brain activity of older people not by requiring them to recite a group of words or remember a string of numbers.

Instead, Reagh looked at a “naturalistic approach,” one that more closely resembled real-world activities.

He found that brain activity in older adults isn’t necessarily quieter when it comes to memory. “It’s just different,” he says.

A movie vs. a memory test

Common tests of memory involve a person’s ability to remember a string of words, count backward, or recognize repeated images. “How many times do you suspect a 75-year-old is going to have to remember, ‘tree, apple, cherry, truck?'” asked Reagh, first author on the paper with Angelique Delarazan, Alexander Garber, and Charan Ranganath, all of the University of California, Davis.

Instead, he used a data set from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) that included functional MRI (fMRI) scans of people watching an 8-minute movie.

“There were no specific instructions, or a ‘gotcha’ moment,” Reagh says. “They just got to kick back, relax, and enjoy the film.”

But while they may have been relaxing, the subjects’ brains were hard at work recognizing, interpreting, and categorizing events in the movies. One particular way people categorize events is by marking boundaries—where one event ends and another begins.

An “event” can be pretty much anything, Reagh says. “This conversation, or a component of it, for example. We take these meaningful pieces and extract them out of a continuous stream.”

And what constitutes a boundary is actually consistent among people.

“If you and I watch the same movie, and we are given the instruction to press a button when we feel one meaningful unit has ended, you and I will be much more similar in our responses than we are different,” Reagh says.

Aging brains

When looking at the fMRI results—which use changes in blood flow and blood oxygen to highlight brain activity—older adults showed similarly increased activity as a control group at the boundaries of events. That’s not to say that brains of all ages are processing the information similarly.

“It’s just different,” Reagh says. “In some areas, activity goes down and, in some, it actually goes up.”

Overall activity did decline pretty reliably across ages 18-88, Reagh says, and when grouped into “younger, middle aged, and older,” there was a statistically reliable drop in activity from one group to another.

“But we did find a few regions where activity was ramped up across age ranges,” he says. “That was unexpected.”

Much of the activity he was interested in is in an area of the brain referred to as the posterior medial network—which includes regions in the midline and toward the backside of the brain. In addition to memory, these areas are heavily involved in representing context and situational awareness. Some of those areas showed decreased activity in the older adults.

“We do think the differences are memory-related,” Reagh says. At the boundaries, they saw differences in the levels of activity in the hippocampus that was related to memory in a different measurement—”story memory,” he called it.

“There might be a broad sense in which the hippocampus’s response to event boundaries predicts how well you are able to parse and remember stories and complex narratives,” no matter one’s age, Reagh says.

But for older adults, closer to the front of the brain, particularly the medial prefrontal cortex, things were looking up.

From specific to ‘gist-like’

Activity in that area of the brain was ramped up in older adults. This area is implicated in broad, schematic knowledge—what it’s like to go to a grocery store as opposed to a particular grocery store.

“What might be happening is as older adults lose some responsiveness in posterior parts of the brain, they may be shifting away from the more detailed contextual information,” Reagh says. But as activity levels heighten in the anterior portions, “things might become more schematic. More ‘gist-like.'”

In practice, this might mean that a 20-year-old noting an event boundary in a movie might be more focused on the specifics—what specific room are the characters in? What is the exact content of the conversation?

An older viewer might be paying more attention to the broader picture—What kind of room are the characters in? Have the characters transitioned from a formal dinner setting to a more relaxed, after-dinner location? Did a loud, tense conversation resolve into a friendly one?

“Older adults might be representing events in different ways, and transitions might be picked up differently than, say, a 20-year-old,” Reagh says.

“An interesting conclusion one could draw is maybe healthy older adults aren’t ‘missing the picture.’ It’s not that the info isn’t getting in, it’s just it’s getting in differently.”

Funding for the research came from the National Institute on Aging; Office of Naval Research; and a University of California, Davis Alzheimer’s Disease Center Pilot Grant.

Source: Washington University in St. Louis