Physical therapy either before or after total knee replacement surgery can reduce the risk of becoming addicted to pain-relieving opioids, according to a new study.
The world’s most common form of arthritis, knee osteoarthritis, causes people pain and hurts their quality of life.
Total knee replacement is the only option for people with severe knee osteoarthritis, but even that invasive surgery still leaves up to a third of patients with chronic knee pain. Many people who undergo total knee replacement surgery go on to become long-term opioid users.
“Osteoarthritis is one of the most common conditions for which opioids are prescribed [in the United States],” says Kosaku Aoyagi, a physical therapist and researcher at Boston University. “With the aging of the population and rising prevalence of osteoarthritis, the number of total knee replacement procedures is expected to rise exponentially over the next decade.”
Now, Aoyagi and colleagues have discovered at least one promising way to reduce a patient’s risk of opioid addiction: Participate in physical therapy either before or after total knee replacement surgery.
Timing of physical therapy matters
In the largest study of its kind, published in JAMA Network Open, Aoyagi and Deepak Kumar, assistant professor of physical therapy, and other collaborators, analyzed more than 67,000 patient records, and discovered that even low levels of physical therapy were associated with lower likelihood of long-term opioid use after total knee replacement.
Specifically, they found that participation in PT within 90 days before or after total knee replacement was associated with lower likelihood of long-term opioid use. Going further, they found that six or more sessions of outpatient physical therapy post-surgery was linked to reduced chance of long-term opioid use, as were instances when outpatient physical therapy was initiated within 30 days of surgery.
Kumar, a physical therapist by training, says the analysis reveals that the longer a patient waits to start outpatient physical therapy after surgery, the greater their odds of long-term opioid use.
But the exact reason why PT reduces the likelihood of opioid use is not yet clear. Aoyagi says a surprising aspect of the findings was that both types of physical therapy—active (exercise) and passive (heating or icing)—were associated with reduced long-term opioid use.
More research is needed to understand the relationship between types of physical therapy interventions with the outcomes in people who undergo total knee replacement, he says.
The study has some important limitations, Kumar says, because it is based on insurance claims data, and lacks more context about individual circumstances. For example, the ability to start and adhere to physical therapy could be linked to a person’s employment, health insurance, and ability to take time away from work and to travel to an outpatient clinic—all factors that a person’s socioeconomic background can affect.
“It’s an equity issue—there are known racial disparities, such as the fact that African Americans are less likely to receive physical therapy than Caucasian patients,” Kumar says. He says that can be related to insurance coverage as well as healthcare provider bias.
Not a one-size-fits-all approach
Still, the findings excited the researchers because they suggest that therapy could be considered an effective therapy for managing pain in people who undergo total knee replacement, rather than relying on steroid shots, nonsteroidal anti-inflammatory drugs (NSAIDs), or other pain relievers.
“Despite treatment guidelines recommending physical therapy for osteoarthritis [as a first line treatment], utilization of physical therapy remains low,” says Aoyagi, a postdoctoral associate at Boston University School of Medicine and a researcher at Boston University’s Arthritis and Autoimmune Diseases Research Center.
“In contrast, opioids are not recommended for osteoarthritis yet are commonly prescribed. Our study adds to the growing body of literature that physical therapy interventions can provide meaningful pain management with much lower risk than many pharmacologic options, including opioids.”
Treating pain associated with knee osteoarthritis cannot be viewed as a one-size-fits-all approach, Kumar says, because previous research has revealed that about half of patients don’t respond to exercise as well as others.
“The future of pain management needs to be a multimodal approach,” Kumar says, “but we’re observing that physical therapy can reduce the odds that a patient will be a long-term opioid user in the future.”
The National Institutes of Health—National Institute of Arthritis and Musculoskeletal and Skin Diseases supported the work.
Source: Boston University