In the four months following the COVID-19 pandemic’s arrival, the number of patients in the US initiating treatment for kidney failure declined by 30%, according to a new study.
Notably, Black patients and patients living in counties with high numbers of COVID-19 deaths initiated treatment with significantly worse levels of kidney function when compared to prior years.
Unfortunately, the results do not mean that patients with chronic kidney disease had fewer incidents of failure or had healthier kidneys, says study lead author Kevin Nguyen, an investigator at Brown University’s School of Public Health.
Rather, the decline in patients with kidney failure likely reflects decisions to delay treatment or changes in how health care was delivered early in the pandemic. Treatments often include regular dialysis or kidney transplants, two options disrupted after COVID-19’s arrival.
“Treatment in the form of dialysis or a transplant is essential for the survival of people with chronic kidney disease,” Nguyen says. “Missed routine care could be potentially catastrophic. So understanding whether and how these initiations of treatment changed with respect to the pandemic is really important.”
Lower kidney function
The goal of the study was to look at how the number and characteristics of patients initiating treatment for newly diagnosed kidney failure changed during the pandemic, Nguyen says. Because the burden of the pandemic has disproportionately affected people of color and members of low-income families, the researchers also wanted to examine changes specifically within those groups.
They used data from the Renal Management Information System Medical Evidence Form, a national census of all patients with kidney failure who initiate long-term dialysis or receive a preemptive kidney transplant.
They studied the changes in the number of patients with kidney failure initiating treatment as well as estimated glomerular filtration rate (eGFR), a key measure of kidney function, for the period of March 1 to June 30, 2020, and compared the numbers to the corresponding periods in 2018 and 2019. The researchers segmented their analysis by race/ethnicity, county-level COVID-19 mortality, and neighborhood socioeconomic characteristics.
Compared to the pre-COVID-19 years, March through June 2020 saw significant decreases in the percentage of patients with kidney failure who received preemptive transplants (2.1% pre-COVID-19 vs. 1.4% during COVID-19) or initiated dialysis treatment (15.8% pre-COVID-19 vs. 13.4% during COVID-19). In April 2020, the number of patients initiating treatment for kidney failure was approximately 30% lower than trends in prior years.
Declines in the measurement of kidney function were observed exclusively among non-Hispanic Black patients (8.4 mL/min/1.73m2 pre-COVID-19 to 8.1 during COVID-19). There were significant declines in eGFR for patients residing in counties with the highest number of deaths from COVID-19 (9.5 vs. 9.2 during the pandemic), but not for patients residing in other counties.
“In the early months of the pandemic, not only were there declines in the number of people initiating treatment for kidney failure, but for some groups, when they did initiate treatment, it was when they had lower kidney function,” Nguyen says.
Continuity of care is important
The largest reduction in the number of patients seeking treatment compared to prior years was in April 2020. Nguyen says that while a gradual rebound in treatment initiation occurred in the later months, it still didn’t reach pre-pandemic levels.
The study findings underscore the importance of maintaining continuity of care and improving care for people with chronic kidney disease, Nguyen says, both throughout the pandemic and after it eventually subsides.
“Any disruption in care can have grave consequences for these patients,” he says.
The study wasn’t designed to examine the specific mechanisms driving these changes, but Nguyen says plausible explanations include patients delaying treatment for fear of getting sick, limited appointment availability, and financial or logistical barriers to accessing care, as caused by the economic repercussions of the pandemic. He also notes that in some cases, the provider and patient together may have decided to postpone a transplant.
The study appears in JAMA Network Open. The National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health supported the work.
Source: Brown University