Children of mothers who had gestational diabetes during pregnancy could be at increased risk of type 1 diabetes themselves, according to a new study.
Early detection of diabetes is important in children and youth, as many—about 25 percent—only receive a diagnosis when seeking care for diabetic ketoacidosis, a potentially life-threatening complication of diabetes that can occur when the body starts running out of insulin.
“Although type 1 and type 2 diabetes in parents are well-established risk factors for their offspring to become diabetic, we show in this study that gestational diabetes may also be a risk indicator for type 1 diabetes in the mother’s children,” says senior study author Kaberi Dasgupta, an associate professor of medicine at McGill University and director and senior scientist of the Centre for Outcomes Research and Evaluation at the Research Institute of the McGill University Health Centre.
“We found that a child or teen whose mother had gestational diabetes was nearly twice as likely to develop type 1 diabetes before the age of 22.”
As reported in the Canadian Medical Association Journal, the study of 73,180 mothers compared data from Quebec (1990-2012) on randomly selected single births from mothers with gestational diabetes to births from mothers without gestational diabetes.
The incidence—the number of new cases—of diabetes per 10,000 person-years was 4.5 in children born to mothers with gestational diabetes and 2.4 in mothers without.
“Only a small number of children will develop diabetes before the age of 22, even if their mothers had gestational diabetes,” says coauthor Meranda Naklha, an assistant professor of pediatrics and a pediatric endocrinologist at the Montreal Children’s Hospital.
“However, parents and healthcare providers should consider the possibility of diabetes if children start showing signs such has frequent urination, excessive thirst, or weight loss, particularly if their moms had gestational diabetes.”
According to the authors, future studies need to examine the reasons for this relationship but the evidence of the link may help to accelerate the diagnosis of diabetes in young people.
“This study is important, as we try to understand risk factors for type 1 diabetes,” says Jan Hux, president and CEO of Diabetes Canada, which funded the research.
“This research may result in a greater propensity for healthcare providers to promptly test children who present with typical diabetes symptoms and who are born to mothers with gestational diabetes, thereby reducing the likelihood of severe incidents like diabetic ketoacidosis. We look forward to improving the lives and outcomes of children through greater research in this area.”
Source: McGill Universit