Fracking chemicals may harm developing immune system

Craig Stevens (L) of Silver Lake Township, Pennsylvania, and Ray Kemble (R) of Dimock, Pennsylvania, show water samples collected from Dimock, Pennsylvania during a rally on fracking-related water investigations October 10, 2014 outside EPA Headquarters in Washington, DC. (Credit: Alex Wong/Getty Images)

Exposure to fracking chemicals in utero may harm the immune system and diminish the ability of female offspring to fend off diseases like multiple sclerosis, according to a new study with mice.

Fracking, also called hydraulic fracturing or unconventional oil and gas extraction, involves pumping millions of gallons of chemical-laden water deep underground to fracture rock and release oil and gas.

About 200 chemicals have been measured in waste water and surface or ground water in fracking-dense regions and several studies have reported higher rates of diseases, like acute lymphocytic leukemia and asthma attacks, among residents in these areas.

“Our study reveals that there are links between early life exposure to fracking-associated chemicals and damage to the immune system in mice,” says Paige Lawrence, chair of environmental medicine at the University of Rochester Medical Center and lead author of the study in Toxicological Sciences.

“This discovery opens up new avenues of research to identify, and someday prevent, possible adverse health effects in people living near fracking sites.”

Endocrine disrupters

Of the 200 fracking chemicals found in ground water, 23 were recently linked to reproductive and developmental defects in mice. Coauthor Susan Nagel, associate professor of reproductive and perinatal research at the University of Missouri School of Medicine, classified the chemicals as endocrine disrupters, meaning they can interfere with hormones and derail hormone-controlled systems.

Because hormones greatly influence the immune system, Lawrence tested the immune impact of those 23 fracking chemicals on mice. Her team added chemicals to the drinking water of pregnant mice at levels similar to those found in ground water near fracking sites.

“Our goal is to figure out if these chemicals in our water impact human health,” Lawrence says, “but we first need to know what specific aspects of health to look at, so this was a good place to start.”

Fracking chemicals linked to precancerous lesions in mice

In Lawrence’s study, mouse pups—particularly females—who were exposed to a mixture of 23 fracking chemicals in the womb had abnormal immune responses to several types of diseases later on, including an allergic disease and a type of flu.

What was most striking: these mice were especially susceptible to a disease that mimics multiple sclerosis, developing symptoms significantly earlier than mice that were not exposed to the chemicals.

Immune function is delicate

At the heart of these abnormal immune responses lies an intricate mosaic of immune cells, each playing specific and important roles defending against infections, or preventing allergies or damage caused by uncontrolled immune responses. Some of these cells jump into action to fight off invaders, while others tamp down an immune response once an infection is under control.

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Proper immune function requires a delicate balance of all of these players—which fracking chemicals appear to disrupt. The researchers believe the chemicals derail cellular pathways that control which immune cells are spurred to action.

The group will continue to investigate how fracking chemicals interact with the developing immune system in hopes of understanding what this could mean for human health.

Source: University of Rochester