Exercise can modify fat tissue in people with obesity

"Most of the benefits of exercise... are relatively short-lived, often lasting only a few days at most," says Jeffrey Horowitz. "This is one of the big reasons why it is so important to be physically active most days." (Credit: Getty Images)

Research suggests that exercise can favorably modify fat tissue just beneath the skin in ways that can improve metabolic health—even without weight loss.

Exercise is one of the first strategies used to treat obesity-related health problems like type 2 diabetes and other cardiovascular disease, but scientists don’t understand exactly how it works to improve metabolic health.

To that end, researchers examined the effects of three months of exercise on people with obesity.

Surprisingly, moderate and high-intensity exercise yielded the same positive changes in fat tissue composition and structure, and fat cells shrank a bit even without weight loss, says Jeffrey Horowitz, a professor of kinesiology at the University of Michigan and principal investigator of the study in the Journal of Physiology.

The study aimed to better understand the effects of exercise on metabolic health in people with obesity. Researchers placed 36 adults with obesity into either a moderate-intensity exercise group (45 minutes, 70% of maximum heart rate) or a high-intensity exercise group (10 one-minute intervals at 90% maximum heart rate interspersed with 60 seconds of low-intensity active recovery).

The researchers collected blood samples and biopsies of abdominal fat the day after the 12-week sessions ended and again three days later. There was no exercise between these tests. Results for both exercise groups showed several structural changes in fat tissue, including slightly smaller fat cells and more of them, increased collagen type, increased capillary density, and changes in proteins that regulate body fat remodeling.

Many of the changes in factors regulating body fat remodeling seen one day after exercise were no longer significant on day 4 of testing, and this underscores the importance of regular, sustained exercise, Horowitz says.

Many adaptations to exercise training are effective in enabling a person to exercise longer or harder, Horowitz says.

“However, most of the benefits of exercise that improve metabolic health in people at risk for metabolic health complications or those who have metabolic disease stems from the response to each exercise session—and these responses to exercise are relatively short-lived, often lasting only a few days at most,” he says. “This is one of the big reasons why it is so important to be physically active most days.”

The finding about moderate and high-intensity exercise yielding similar responses could be good news for people who prefer to avoid the more demanding high-intensity interval training, or HIIT.

“Our findings suggest that options are open,” Horowitz says. “The similar response between HIIT and more conventional moderate-intensity exercise was among the bigger surprises to us. It is impressive that we observed very similar responses despite rather large differences in the exercise stimulus (exercise time, kcals expended, intensity) between these two training programs.”

While the findings aren’t related to weight loss, they are related to metabolic health and disease prevention in people with obesity, and these in turn impact quality of life, Horowitz says.

“Even though some of our favorable outcomes were relatively short-lived, some are longer lasting, like capillary density of fat tissue and fat cell structure,” he says. “Therefore, we hypothesize that a physically active lifestyle may help protect people from developing some chronic metabolic health complications if or when they do gain weight as they age, and evidence strongly indicates that most of us, even regular exercisers, gain weight as we age.”

Horowitz says it’s important for people to understand that fat tissue is simply where our bodies store extra energy, and it’s not the reason people gain weight.

“Weight gain can only occur if you eat more calories than you expend. And in situations when we do gain weight, especially to the point where people are approaching or become obese, it is ideal to have so-called healthy fat tissue in which to store this extra energy.”

Doctoral student Cheehoon Ahn and Ben Ryan, a postdoctoral research fellow now at the US Army Research Institute of Environmental Medicine, are the study’s co-first authors.

Source: University of Michigan