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blood clots

Pill can battle deadly blood clots in cancer patients

A blood-thinning drug can help treat cancer patients for a potentially deadly condition, according to new research.

People with cancer have an increased risk of developing blood clots, with roughly one in five experiencing venous thromboembolism (VTE)—either deep vein thrombosis (DVT) or pulmonary embolism (PE). Blood clots in the deep veins of the leg may travel to the lungs causing a pulmonary embolism. VTE is a dangerous and potentially deadly medical condition with 10 million cases worldwide.

“…this form of treatment is an alternative option for many cancer patients who have a clot.”

Current international guidelines recommend cancer patients receive an injection with an anticoagulant (a low molecular weight heparin) to treat and prevent recurrence of VTE. New results from a large pilot trial run called “select-d,” however, suggest that a daily tablet could be a beneficial alternative for treating VTE in selected patients.

The pilot trial found that prescribing the oral drug rivaroxaban (Xarelto) significantly reduced venous thromboembolism recurrence among patients with cancer and VTE.

“Clinicians were already adopting the oral drug into practice for non-cancer patients and now they have data from this study to indicate that this form of treatment is an alternative option for many cancer patients who have a clot,” says Annie Young, a professor at the University of Warwick Medical School who led the research.

Although there are many causes and risk factors for VTE, cancer patients are particularly at risk due to a combination of factors, including immobility, pancreatic and gastric tumors, and chemotherapy. Because VTE can be life-threatening, blood thinners are used to shrink existing clots and prevent others from forming.

The “select-d” trial enrolled 406 patients who had cancer and VTE; most (69 percent) were receiving cancer treatment (typically chemotherapy) at the time of their VTE. The researchers randomly assigned half to a group that received low-molecular-weight heparin (dalteparin) and half received the oral drug rivaroxaban. After six months of treatment, the VTE recurrence rate was four percent among those taking the tablet and 11 percent in those receiving dalteparin.

Costly blood clot procedure may not be worth the risk

The results for secondary outcomes were mixed. In patients receiving rivaroxaban, there were around the same percentage of major bleeding events (6 percent) as those receiving dalteparin (4 percent) but a marked and significant increase in clinically relevant non-major bleeds (13 percent) with rivaroxaban compared to those having low molecular weight heparin (4 percent). The reason for increased bleeding is unknown, it may be because rivaroxaban is more “potent.”

“We now need to be sitting down with each one of our cancer patients with VTE, discussing their preference alongside looking at all their clinical details including whether the cancer lesion is still there, what other medications are being taken, and what other conditions the patient has so that we can choose the optimal VTE treatment for each patient,” Young adds.

The researchers report their findings in the Journal of Clinical Oncology.

Source: University of Warwick

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