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These dentures deliver drugs to battle infection

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The dentures are printed using acrylamide, the current go-to material for denture fabrication. (Credit: Douglas Levere/U. Buffalo)

Researchers have created 3D-printed dentures that can deliver drugs to prevent the kinds of infections that affect so many people who use artificial teeth.

Nearly two-thirds of the US denture-wearing population suffer frequent fungal infections that cause inflammation, redness, and swelling in the mouth.

To better treat these infections, called denture-related stomatitis, researchers turned to 3D printers, using the machines to build dentures filled with microscopic capsules that periodically release Amphotericin B, an antifungal medication.

The technology allows clinicians to rapidly create customized dentures chair-side, a vast improvement over conventional manufacturing…

A study describing the work in Materials Today Communications finds that the drug-filled dentures can reduce fungal growth. Unlike current treatment options, such as antiseptic mouthwashes, baking soda, and microwave disinfection, the new development can also help prevent infection while the dentures are in use.

“The major impact of this innovative 3D printing system is its potential impact on saving cost and time,” says Praveen Arany, the study’s senior author and an assistant professor in the oral biology department of the University at Buffalo School of Dental Medicine.

The technology allows clinicians to rapidly create customized dentures chair-side, a vast improvement over conventional manufacturing that can vary from a few days to weeks, says Arany.

Arany says that various other clinical therapies, including splints, stents, casts, and prosthesis could take applications from this research.

“The antifungal application could prove invaluable among those highly susceptible to infection, such as the elderly, hospitalized, or disabled patients,” he says.

The dental biomaterials market—worth more than $66 billion in 2015—is expected to grow 14 percent by 2020. A large part of the industry is focused on dental polymers, particularly the fabrication of dentures.

The researchers printed their dentures with acrylamide, the current go-to material for denture fabrication. The study sought to determine if these dentures maintained the strength of conventional dentures and if the material could effectively release antifungal medication.

To test the strength of the teeth, researchers used a flexural strength testing machine to bend the dentures and discover their breaking points. They used a conventional lab-fabricated denture as a control. Although the flexural strength of the 3D printed dentures was 35 percent less than that of the conventional pair, the printed teeth never fractured.

To examine the release of medication in the printed dentures, the team filled the antifungal agent into biodegradable, permeable microspheres. The microspheres protect the drug during the heat printing process, and allow the release of medication as they gradually degrade.

This stuff could rebuild teeth and cure cavities

The investigation involved the development of an innovative form of acrylamide designed to carry antifungal payloads, and a novel syringe pump system to combine the dental polymer and microspheres during the printing process.

The researchers tested the dentures with one, five, and 10 layers of material to learn if additional layers would allow the dentures to hold more medication. The researchers found the sets with five and 10 layers were impermeable and ineffective at dispensing the medication. The more porous single layer didn’t hinder the release, and successfully reduced fungal growth

Future research aims to reinforce the mechanical strength of 3D printed dentures with glass fibers and carbon nanotubes, and focus on denture relining—the readjustment of dentures to maintain proper fit.

Source: University at Buffalo

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