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Is autism more common that we thought?

The number of children in the United States diagnosed with autism spectrum disorder may be significantly higher than previously thought, a new analysis suggests.

The analysis of data from the US Centers for Disease Control and Prevention (CDC) suggests that 2.4 percent of American children between the ages of 3 and 17—or 1 in 41—have been diagnosed with autism, a figure that is higher than most earlier estimates of about 1.46 percent or 1 in 68 children.

The higher number shows the need for officials to think about reallocating health care resources to care for significantly more people with autism, says Wei Bao, assistant professor of epidemiology at the University of Iowa and corresponding author of the analysis, which appears in the Journal of the American Medical Association.

“Clearly, we need more people to care for children with autism.”

“Previous thinking about autism is that it is very rare, but this study tells us that it is no longer something that is very rare,” says Bao. “This should cause us to reconsider what our future priorities in research, service, and policy should be regarding children who have autism spectrum disorder. Clearly, we need more people to care for children with autism.”

Researchers used nationally representative data from the CDC’s National Health Interview Survey from 2014 to 2016, which collects data on a broad range of health topics through thousands of in-person household interviews each year. As part of the interview, survey-takers ask respondents if the randomly sampled child living in the household has ever been diagnosed with autism.

Bao says the previous estimate of 1.46 percent was derived from the CDC’s Autism and Disabilities Monitoring Network (ADDM), which collects data from the health and special education records of 8-year-old children at 11 selected sites across the United States.

The new analysis was based on a nationally representative sample of children ages 3 to 17 and Bao cautions that these methodological differences in study design make direct comparisons between the two databases difficult.

The analysis also confirms earlier findings about gender and racial/ethnic disparity of autism in US children, that it is much more frequent in boys (3.54 percent) than girls (1.22 percent), and less frequent in people of Hispanic origin (1.78 percent) than in non-Hispanic whites (2.71 percent) or non-Hispanic blacks (2.36 percent).

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The analysis also found the highest prevalence of autism in Northeast states, at 3.05 percent, followed by the Midwest at 2.47 percent, the West at 2.24 percent, and the South at 2.21 percent. Bao speculates that rates are lower in the South and West because higher percentages of the population living in those states are Hispanic, a population that tends to have a lower prevalence of autism overall.

Bao says the limitation of the analysis is that the data is self-reported by the household respondent to the CDC survey-taker and is not subject to any third-party adjudication.

The analysis doesn’t identify a cause for the increasing number of autism spectrum disorder cases. Bao says greater awareness among parents and health care providers might be the cause of some of the increase, but environmental and genetic factors likely are responsible for a large part of the gap.

Bao points to previous studies that show children are at greater risk of autism if their mothers have diabetes before or during pregnancy; since diabetes is often caused by obesity, the increase could be linked to the increasing weight of Americans.

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“Autism is a highly complex disease caused by multiple genetic and environmental factors,” Bao says. “Maternal diabetes could be one of those factors, but it is not the only one. We need to find more about the underlying driving factors.”

Guifeng Xu, a PhD candidate and graduate research assistant, is the study’s first author.

Source: University of Iowa

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