Researchers are testing flexible wireless implants that could be used in different parts of the body to fight pain that doesn’t respond to other therapies.
Unlike devices that need to anchored to bone, these are soft and stretchable, which means they can be implanted into parts of the body that move, says Robert W. Gereau, one of the study leaders and an anesthesiology professor at Washington University School of Medicine in St. Louis.
“Our eventual goal is to use this technology to treat pain in very specific locations by providing a kind of ‘switch’ to turn off the pain signals long before they reach the brain,” says Gereau.
“But when we’re studying neurons in the spinal cord or in other areas outside of the central nervous system, we need stretchable implants that don’t require anchoring,” he adds.
The new devices are held in place with sutures. Like the previous models, they contain microLED lights that can activate specific nerve cells. Gereau hopes to use the implants to blunt pain signals in patients who have pain that cannot be managed with standard therapies.
The researchers experimented with mice that were genetically engineered to have light-sensitive proteins on some of their nerve cells. To demonstrate that the implants could influence the pain pathway in nerve cells, the researchers activated a pain response with light.
When the mice walked through a specific area in a maze, the implanted devices lit up and caused the mice to feel discomfort. When they left that part of the maze, the devices turned off, and the discomfort dissipated. As a result, the animals quickly learned to avoid that part of the maze.
The experiment would have been very difficult with older optogenetic devices, which are tethered to a power source and can inhibit the movement of the mice.
Because the new devices are flexible and can be held in place with sutures, they also may have potential uses in or around the bladder, stomach, intestines, heart, or other organs, says John A. Rogers, a professor of materials science and engineering at the University of Illinois, who co-led the study.
“They provide unique, biocompatible platforms for wireless delivery of light to virtually any targeted organ in the body,” he says.
Rogers and Gereau designed the implants with an eye toward manufacturing processes that would allow for mass production so the devices could be available to other researchers. They and colleagues have launched a company called NeuroLux to aid in that goal.
Funding from the National Institutes of Health and other fellowship awards supported the study, which appears in the Nature Biotechnology.