U. BUFFALO (US) — Doctors will be able to diagnose the painful autoimmune disease Sjogren’s syndrome much earlier, thanks to the discovery of novel antibodies.
The breakthrough, described in a paper in the December issue of Clinical Immunology, will allow patients to be treated sooner when they are much more likely to benefit.
“Sjogren’s patients get diagnosed too late,” says Julian L. Ambrus Jr., professor in the Department of Medicine in the University at Buffalo School of Medicine and Biomedical Sciences. “They go to the doctor because their eyes are dry or they can’t swallow, but by that time, their salivary or tear glands are already dead. They’re way past the point where they can generally benefit from any treatment.”
The new antibodies were seen in 45 percent of patients who met most of the clinical criteria for Sjogren’s except for the antibodies currently required for diagnosis, called Ro and La.
At least one of the novel antibodies is present in 76 percent of patients who have had symptoms for less than two years and who also lacked the two antibodies required for definitive diagnosis, which appear late in the disease.
“The vast majority of patients we tested who have early symptoms of severe dry mouth and dry eyes also have these antibodies,” says Ambrus, who is also an immunologist at Buffalo General Medical Center and senior author on the paper.
The journal highlights the research paper with an editorial by Robert I. Fox, of Scripps/Ximed, considered one of the world’s top Sjogren’s Syndrome scientists.
Considered one of the three most common autoimmune diseases, Sjogren’s Syndrome affects more than 4 million Americans, 90 percent of whom are women. Last year, tennis champion Venus Williams announced that she had the disease.
Symptoms are dry eyes and dry mouth so severe that they are painful. Despite its high incidence, Sjogren’s is not well-known and can take years to diagnose; once diagnosed, it is often too late to effectively treat it.
Beyond the chronic pain associated with not being able to produce tears or saliva, the disease is associated with additional, systemic consequences, such as mild kidney and lung disease. Five to ten percent of Sjogren’s patients also will develop lymphoma, cancer of the lymphocytes, a type of white blood cell that is continually produced in Sjogren’s Syndrome.
“Our animal model has completely changed how people think about this disease,” says Ambrus. “Sjogren’s disease in our animal model marches along in exactly the same way that the human disease does, reproducing every stage of the disease.”
Once the new antibodies were detected in mice, the scientists started testing human patients at Buffalo General Medical Center. The researchers found the same antibodies in humans even at early stages of the disease.
University at Buffalo has filed a patent on the biomarker-based method and licensed the technology to Immco, which has developed a new diagnostic tool based on the research.
“We believe this is one of the most undiagnosed autoimmune diseases,” says William Maggio, chief executive officer of Immco.
And because Sjogren’s Syndrome presents with various symptoms, unlike other autoimmune diseases, this diagnostic test will be marketed to several different types of physicians, including dentists, oral surgeons, ophthalmologists, and rheumatologists.
The assay will undergo validation by the New York State Department of Health. Once complete early next year, physicians will be able to start using the test. Patient samples from around the nation will be sent to Immco for testing. Immco also is developing a diagnostic kit for customers to be marketed internationally.
Already, the scientists have begun collaborating with several international groups working on Sjogren’s Syndrome, giving them access to many more patients.
Source: University at Buffalo