Tardigrades are nearly microscopic animals that can survive the harshest of environments, including outer space.
Scientists sequenced their genome and were shocked to find the animals, known as water bears, get a huge chunk—about 17 percent—from foreign DNA.
Stick a tardigrade in an 80-celsius freezer for 10 years and it starts running around in 20 minutes after thawing.
Previously another microscopic animal called the rotifer was the record-holder for having the most foreign DNA, but it has about half as much as the tardigrade. For comparison, most animals have less than one percent of their genome from foreign DNA.
“We had no idea that an animal genome could be composed of so much foreign DNA,” says study co-author Bob Goldstein, a researcher at the University of North Carolina at Chapel Hill. “We knew many animals acquire foreign genes, but we had no idea that it happens to this degree.”
The work, publish in the Proceeding of the National Academy of Sciences, not only raises the question of whether there is a connection between foreign DNA and the ability to survive extreme environments, but further stretches conventional views of how DNA is inherited.
The study shows that tardigrades acquire about 6,000 foreign genes primarily from bacteria, but also from plants, fungi, and Archaea, through a process called horizontal gene transfer—the swapping of genetic material between species as opposed to inheriting DNA exclusively from mom and dad.
“Animals that can survive extreme stresses may be particularly prone to acquiring foreign genes—and bacterial genes might be better able to withstand stresses than animal ones,” says Thomas Boothby, a postdoctoral fellow in Goldstein’s lab and first author of the study. After all, bacteria have survived the Earth’s most extreme environments for billions of years.
The team speculates that the DNA is getting into the genome randomly but what is being kept is what allows tardigrades to survive the harshest of environments: Stick a tardigrade in an 80-celsius freezer for 10 years and it starts running around in 20 minutes after thawing.
This is what the team thinks happens
When tardigrades are under conditions of extreme stress such as desiccation—or a state of extreme dryness—Boothby and Goldstein believe that the tardigrade’s DNA breaks into tiny pieces.
When the cell rehydrates, the cell’s membrane and nucleus, where the DNA resides, becomes temporarily leaky and DNA and other large molecules can pass through easily. Tardigrades not only can repair their own damaged DNA as the cell rehydrates but also stitch in the foreign DNA in the process, creating a mosaic of genes that come from different species.
“We think of the tree of life, with genetic material passing vertically from mom and dad,” says Boothby. “But with horizontal gene transfer becoming more widely accepted and more well known, at least in certain organisms, it is beginning to change the way we think about evolution and inheritance of genetic material and the stability of genomes.
“So instead of thinking of the tree of life, we can think about the web of life and genetic material crossing from branch to branch. So it’s exciting. We are beginning to adjust our understanding of how evolution works.”
Source: UNC-Chapel Hill