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"That was a big surprise for us that those very quiescent sweat gland stem cells maintain multilineage plasticity—participating not only in their own regeneration, but also in the regeneration of hair follicles and skin after injury," says Krzysztof Kobielak. (Credit: "woman flexing" via Shutterstock, font by Vernon Adams)

burns

How sweat glands could help fix wounds

Scientists turned sweat gland stem cells fluorescent green and their findings show promise for treating burns as well as sweating disorders.

Over time, the green fluorescent protein (GFP) became dimmer as it was diluted among dividing sweat gland cells. After four weeks, the only cells that remained fluorescent were the ones that did not divide or divided very slowly—a known property among stem cells of certain tissues, including the hair follicle and cornea.

Therefore, these slow-dividing, fluorescent cells in the sweat gland’s coiled lower region were likely also stem cells.

Then, the first author of the paper, University of Southern California graduate student Yvonne Leung, tested whether these fluorescent cells could do what stem cells do best—differentiate into multiple cell types.

To the researchers’ surprise, these glowing cells generated not only sweat glands, but also hair follicles when placed in the skin of a mouse without GFP.

As reported in PLOS ONE, the researchers also determined that, under certain conditions, the sweat gland stem cells could heal skin wounds and regenerate all layers of the epidermis.

“That was a big surprise for us that those very quiescent sweat gland stem cells maintain multilineage plasticity—participating not only in their own regeneration, but also in the regeneration of hair follicles and skin after injury,” says Krzysztof Kobielak, assistant professor of pathology at USC.

This offers exciting possibilities for developing future stem cell-based treatments for skin and sweat gland-related conditions, such as hyperhidrosis or hypohidrosis (excessive or insufficient sweating). It could also lay the foundation for creating fully functional skin—containing both sweat glands and hair follicles—for burn victims.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health supported the research.

Source: USC

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