UC IRVINE (US)—The most common type of stroke can be completely prevented in rats by stimulating a single whisker, according to a new study.
Strokes are the No. 3 cause of death in the United States, after heart disease and cancer, striking about 795,000 Americans each year—more than 137,000 fatally, according to the American Heart Association.
So should we be tickling our own whiskers? And what about women, who are less likely to have facial hair?
While it’s too soon to tell if the findings will translate to humans, researchers say it’s possible, and stubble is not required.
People have sensitive body parts wired to the same area of the brain as rodents’ fine-tuned whiskers.
“Stimulating the fingers, lips or face in general could all have a similar effect,” says Melissa Davis, University of California at Irvine graduate student and co-author of the study, which appears in the June issue of PLoS One.
“It’s gender-neutral,” adds co-author Ron Frostig, professor of neurobiology and behavior, stressing that the research, funded by the National Institutes of Health, is a first step, albeit an important one.
“This is just the beginning of the whole story,” he says, “with the potential for maybe doing things before a victim even reaches the emergency room.”
A stroke usually happens when a main artery bringing oxygen and nutrients to the brain either ruptures or is blocked by a clot, causing partial brain death.
The key to preventing strokes in rats whose main cerebral artery has been obstructed is to stimulate the blood starved brain area.
Mechanically stroking just one whisker for four minutes within the first two hours of the blockage causes the blood to quickly flow to other arteries—like cars exiting a gridlocked freeway to find detours.
But unlike freeway off-ramps, which can quickly clog, the alternate arteries expanded beyond their normal size, opening wide enough to allow critical blood flow to the brain.
The technique was 100 percent effective in preventing strokes in rats with arterial obstruction.
UC San Diego neuroscientist David Kleinfeld, who has also studied brain structure and strokes, calls the results “unexpected and spectacular.”
Random stimulation of the rat whisker also worked, but timing was critical—waiting three hours to do so led to major brain cell death.
Scientists have struggled for years to find ways of preventing strokes or minimizing their effects, which include slurred speech, paralysis, and brain damage. One drug can help some patients but also often causes bleeding in the brain.
People believed to be suffering a stroke are currently told to lie still and stay calm in a quiet environment. Frostig says a good massage, listening to a song or otherwise stimulating the right nerve endings might work better.
Kleinfeld cautions that the rodent findings might not be relevant to humans. But with such clear evidence that strokes in rats were prevented, he says, “it would be criminal not to try” controlled human studies.
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