cancer

Seizure med may combat kidney condition

PKD2

“Currently there is no directed therapy, but it is a slow progressing disease, which frequently takes decades to develop symptoms,” lead researcher Zhaoxia Sun says. “Therefore, a treatment of even modest efficacy could have significant clinical impact.”

YALE (US)—An anticonvulsant drug commonly used to treat epilepsy reduces cysts in mice that are associated with polycystic kidney disease (PKD), a difficult-to-treat ailment that afflicts 600,000 people in the United States.

“This is exciting because the drug (valproic acid) is also in clinical trials as a potential cancer drug and has a known safety profile,” says lead researcher Zhaoxia Sun, associate professor of genetics at Yale University.

Sun’s lab began searching for chemical compounds that would suppress the effects of one of two genes known to cause the most common form of PKD, which is the fourth leading cause of kidney failure. The screens identified a class of molecules called HDAC inhibitors as potential drug candidates. These inhibitors eliminated the curve tail in zebrafish, a defect associated with the PKD-causing gene.

The epilepsy drug valproic acid, marketed under brand names such as Depakote, is also a HDAC inhibitor. So Sun’s collaborator Stefan Somlo, professor of internal medicine and genetics at Yale School of Medicine, used the drug to treat mice with PKD. The team noted that treated mice showed a marked reduction of cysts and improved kidney function.

Sun observed that multiple HDAC inhibitors are being developed as anti-cancer drugs and each would be a potential candidate to treat PKD.

“Currently there is no directed therapy, but it is a slow progressing disease, which frequently takes decades to develop symptoms,” Sun says. “Therefore, a treatment of even modest efficacy could have significant clinical impact.”

The paper published online in the Proceedings of the National Academy of Sciences. Edward Mallinckrodt Jr. Foundation and the National Institute of Diabetes and Digestive and Kidney Diseases funded the study.

Yale University news: http://opa.yale.edu/

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