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Prenatal exposure to DDT linked to hypertension

UC DAVIS (US) — Girls exposed to high levels of the pesticide DDT while in the womb are three times more likely to develop high blood pressure as adults.

Previous studies have shown that adults exposed to DDT (dichlorodiplhenyltrichloroethane) have an increased risk of high blood pressure, but the study published in Environmental Health Perspectives is the first to link prenatal DDT exposure to hypertension in adults.

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Hypertension, or high blood pressure, is a high risk factor for heart disease, which remains the leading cause of death in the United States and worldwide.

“The prenatal period is exquisitely sensitive to environmental disturbance because that’s when the tissues are developing,” says study lead author Michele La Merrill, an assistant professor in the University of California, Davis department of environmental toxicology.

The US Environmental Protection Agency banned DDT in this country in 1972 after nearly three decades of use. However, the pesticide is still used for malaria control in other parts of the world, such as India and South Africa. That means children born in those areas could have a higher risk of hypertension as adults.

La Merrill says that traces of DDT, a persistent organic pollutant, also remain in the food system, primarily in fatty animal products.

The study examined concentrations of DDT in blood samples collected from women who had participated in the Child Health and Development Studies (CDHS), an ongoing project of the nonprofit Public Health Institute.

The CHDS recruited women who sought obstetric care through Kaiser Permanente Foundation Health Plan in the San Francisco Bay Area between 1959 and 1967. They also surveyed the adult daughters of those women to learn if they had developed hypertension.

“Evidence from our study shows that women born in the US before DDT was banned have an increased risk of hypertension that might be explained by increased DDT exposure,” says La Merrill. “And the children of people in areas where DDT is still used may have an increased risk, as well.”

Researchers from the Public Health Institute and Columbia University co-authored the study, which was funded by the National Institutes of Health.

Source: UC Davis

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