antioxidants

Order an OJ with those super-sized fries

orange_juice

“Our data show, for the first time to our knowledge, that drinking orange juice with a meal high in fat and carbohydrates prevented the marked increases in reactive oxygen species and other inflammatory agents,” says Husam Ghanim, first author on the study and a research assistant professor at the University at Buffalo. “This did not happen when participants drank water or a sugary drink with the meal.” (Courtesy: iStockphoto)

U. BUFFALO (US)—Eating foods that contain flavonoids—such as orange juice—can neutralize some of the unhealthy effects of a high-fat, high-carb feast.

Flavonoids appear to counteract the oxidative and inflammatory stress generated by such unhealthy food and to help prevent blood vessel damage, a new study by University at Buffalo endocrinologists shows.

Free radicals, or reactive oxygen species, are known to induce inflammation in blood vessel linings and contribute to the risk of heart attack and stroke. Study researchers say the potent preventative effect of orange juice likely is linked to its heavy load of the flavonoids naringenin and hesperidin, which are major antioxidants.

“Our data show, for the first time to our knowledge, that drinking orange juice with a meal high in fat and carbohydrates prevented the marked increases in reactive oxygen species and other inflammatory agents,” says Husam Ghanim, first author on the study and a research assistant professor.

“This did not happen when participants drank water or a sugary drink with the meal,” he says. “These issues of inflammation following a meal are important because the resultant high glucose and high triglycerides are known to be related to the development of cardiovascular events.”

The findings appear in the March issue of the American Journal of Clinical Nutrition.

The study involved three groups of 10 normal-weight, healthy men and women between the ages of 20 and 40. After an overnight fast, participants ate a 900-calorie breakfast composed of an egg “muffin” sandwich, a sausage “muffin” sandwich, and a serving of hash browns. The meal contained 81 grams of carbohydrates, 51 grams of fat, and 32 grams protein.

Along with the breakfast, one group drank 300 calories of “not-from-concentrate” orange juice, a second group drank a 300-calorie glucose drink, and the third group drank an equal amount of water. All participants were given 15 minutes to finish their food and drink. Blood samples were collected before the meal and at 1, 3, and 5 hours afterwards. There was no significant difference in inflammatory mediators among the groups before the meal.

Analysis of the samples after the meal showed that oxygen free radicals increased an average of 62 percent with water, 63 percent with the glucose, and 47 percent with orange juice. There also was an increase in blood components known as toll-like receptors, which play an important role in the development of inflammation, atherosclerosis, obesity, insulin resistance, and injury to cardiac cells than can occur after a blocked vessel is reopened.

Orange juice also prevented a significant increase in SOCS-3, an important mediator of insulin resistance, which contributes to development of type 2 diabetes.

“These data emphasize that a high-fat, high-carbohydrate meal is profoundly and rapidly proinflammatory, and that this process occurs at the cellular and molecular level,” says Paresh Dandona, senior author of the study, distinguished professor of medicine, and director of the Diabetes-Endocrinology Center of Western New York at Kaleida Health.

“In addition, specific proinflammatory genes are activated after the intake of glucose and a high-fat, high-carbohydrate meal, and these changes are observed in mononuclear cells that participate in vascular inflammation and insulin resistance,” he says.

“These observations extend our previous work showing oxidative and inflammatory stress following such meals by demonstrating a remarkable increase in the mediators of insulin resistance after a single meal, and the equally remarkable prevention of these changes following the intake of orange juice.”

Dandona emphasizes that vascular inflammation is an essential component of atherosclerosis, and that this inflammation may become permanent if a person consumes similar meals regularly.

“The choice of safe foods that are not proinflammatory may provide protection from the unending cycle of postprandial and cumulative inflammation,” he says. “This choice may lower the risk of atherosclerosis and resistance to insulin.”

The research is supported by grants from the Florida Department of Citrus, the National Institutes of Health, and the American Diabetes Association.

University at Buffalo news: www.buffalo.edu/news/

Related Articles