Studying how dogs, rather than rodents, respond to experimental treatments for spinal injuries can offer a more realistic picture of how humans might respond to the same treatments.
Nick Jeffery, professor of neurology and neurosurgery in the Iowa State University College of Veterinary Medicine, says the tightly controlled laboratory conditions for rodents bear little resemblance to the clinical reality of human spinal injuries.
But pet dogs that spontaneously suffer spinal injuries can offer a much closer match.
“Lab conditions aren’t always useful for a good understanding of human clinical injuries,” he adds. “But some of what we see in dogs is a step closer to how humans may respond to new treatments.”
Improvement but not magic
Jeffery has looked closely at two different experimental treatment methods. The first involved culturing cells that connect a dog’s brain to its nose and then transferring the cells to the spinal cord.
Jeffery is currently studying the effect of chondroitinase, an enzyme that can break down scar tissue when injected into the spinal cord of a paralyzed dog.
While the results of the cell studies fall short of miraculous—paralyzed dogs don’t suddenly start running around the park again—the treatments often result in a smoother and wider range of motion for injured dogs, he notes.
And a few individual cases have shown dramatic improvements.
“It’s an improvement, but it’s not magic,” Jeffery cautions.
Finding the right dogs
Jeffery looks for specific characteristics in candidate dogs that can be accepted to receive the experimental treatment. For starters, candidates must fit a certain weight range and suffer from a severe spinal cord injury near the middle of the back.
Beyond that, Jeffery will only take candidates he’s certain won’t benefit from conventional treatments and therapy, a requirement that greatly reduces the pool of eligible subjects.
It’s common among dogs for the discs between vertebrae to degenerate and rupture, he says. But the vast majority of those cases improve with traditional treatment. It’s the dogs that don’t get better that Jeffery wants to study.
A research grant allows Jeffery to administer the treatments free of charge to dog owners whose animals are accepted.
“I’m a believer in the idea that veterinarians should be working in important areas of medical science for the benefit of both pets and people,” he says.
Source: Iowa State University