Neuron predicts if we’ll save or splurge

YALE (US) — Save for retirement or buy the BMW? It’s possible to predict which choice a person will make by eavesdropping on the activity of a single brain cell.

In a study published in the journal Neuron, researchers at Yale University helped identify areas of the brain involved in the decision to delay gratification or indulge, which involves a network that links multiple areas of the brain in a sort of complex feedback loop.

“But in the instant before the choice is made, we can predict the outcome of the decision by listening to the firing activity in a single neuron,” says Daeyeol Lee, associate professor of neurobiology and psychology and senior author of the study.

Scientists have described in general terms how the brain responds to potential rewards, such as food, alcohol or sex. However, Lee’s team looked at the information processed at the level of both brain regions and individual cells.

They recorded activity in individual neurons of monkeys as they were offered choices between smaller rewards or larger ones, which were delivered after delays. Like humans, monkeys tend to opt for immediate gratification.

They found in hundreds of tests that the activity of a single brain cell differed depending upon whether the monkey sought immediate award or delayed one.

The firing of individual neurons were part of a larger regional pattern of activity. The researchers found that the basal ganglia, an area of the brain best known for controlling motor function, appears to help assess both the magnitude of the reward and the time it takes for the reward to be received. In an earlier study,

Lee’s team found that the prefrontal cortex, an area of the brain associated with working memory and rational thinking, played a similar function. They also found that two areas of the basal ganglia play quite different roles. One area, the dorsal striatum, helps target the reward and a second, the ventral striatum, helps evaluate the reward already chosen.

This pattern reveals an important piece of the puzzle regarding how the prefrontal cortex and areas closely connected to it, such as the basal ganglia, orchestrate their activity to reach a consensus when different goals create a conflict.

“We don’t know the anatomical basis of lots of the psychiatric disorders, problem gambling, or impulsive behavior,” Lee says. “Now we are starting to pinpoint those areas, even down to individual neurons.”

The research was funded by the National Institutes of Health.

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