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No one really knows the size of the neural networks involved in initiating movements, but researchers estimated that about 100,000 neurons are involved in launching a simple eye movement. "One of the main questions we addressed is how ensembles of 100,000 neuron accumulators can produce behavior that is also explained by a single accumulator," says Jeffrey Schall. (Credit: Didier-Lg/Flickr)

brains

How big teams of neurons work together so fast

Last spring, President Obama established the federal BRAIN Initiative to give scientists the tools they need to get a dynamic picture of the brain in action.

To do so, the initiative’s architects envision simultaneously recording the activity of complete neural networks that consist of thousands or even millions of neurons.

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However, a new study indicates that it may be possible to accurately characterize these networks by recording the activity of properly selected samples of 50 neurons or less—an alternative that is much easier to realize.

A team of cognitive neuroscientists at Vanderbilt University performed the study, which appears early online in the Proceedings of the National Academy of Sciences.

Response time

The paper describes the results of a computer simulation that the team designed to understand the behavior of the networks of hundreds of thousands of neurons that initiate different body movements: specifically, how the neurons are coordinated to trigger a movement at a particular point in time, called the response time.

The researchers were surprised to discover that the range of response times produced by the simulated population of neurons did not change with size: A network of 50 simulated neurons responded with the same speed as a network with 1,000 neurons.

For decades, response time has been a core measurement in psychology. “Psychologists have developed powerful models of human responses that explain the variation of response time based on the concept of single accumulators,” says Gordon Logan, professor of psychology.

In this model, the brain acts as an accumulator that integrates incoming information related to a given task and produces a movement when the amount of information reaches a preset threshold. The model explains random variations in response times by how quickly the brain accumulates the information it needs to act.

Working together

Meanwhile, neuroscientists have related response time to measurements of single neurons. “Twenty years ago we discovered that the activity of particular neurons resembles the accumulators of psychology models. We haven’t understood until now how large numbers of these neurons can act collectively to initiate movements,” says Jeffrey Schall, professor of neuroscience.

No one really knows the size of the neural networks involved in initiating movements, but researchers estimated that about 100,000 neurons are involved in launching a simple eye movement.

“One of the main questions we addressed is how ensembles of 100,000 neuron accumulators can produce behavior that is also explained by a single accumulator,” Schall says.

“The way that the response time of these ensembles varies with ensemble size clearly depends on the ‘stopping rules’ that they follow,” explains co-author Thomas Palmeri, associate professor of psychology.

For example, if an ensemble doesn’t respond until all of its member neurons have accumulated enough activity, then its response time would be slower for larger networks. On the other hand, if the response time is determined by the first neurons that react, then the response time in larger networks would be shorter than those of smaller networks.

Another important factor is the degree to which the ensemble is coordinated. “The more the ensemble is coordinated, the more the collective resembles a single accumulator. What has been unknown is how much coordination is necessary for the ensemble to act in unison, ” says Bram Zandbelt, a post-doctoral fellow and lead author on the paper.

To address this problem, the researchers developed a new type of computer simulation, one that models the collective behavior of different numbers of accumulators given different amounts of variation in the rates of accumulation.

Extreme cases

The simulation took a tremendous amount of computer power. Even using Vanderbilt’s in-house supercomputer at the Advanced Computing Center for Research & Education, Zandbelt was limited to modeling networks containing 1,000 neurons.

The researchers found that the networks did not produce realistic response times if responses were initiated when only a few or almost all of the simulated neurons finished accumulating, or if the simulated neurons had very different accumulation rates.

However, the networks produced realistic response times over a broad range of stopping rules and similarity in accumulation rates, showing that within these broad constraints, size doesn’t matter. “We were surprised to discover that the networks behaved with a remarkable uniformity except under extreme assumptions,” says Schall.

“As far as the response time goes, the bottom line is that we found that the size of the neural network doesn’t matter under a large set of conditions. If this is true for networks ranging from 10 to 1,000 neurons, it should also hold for networks of 10,000 to 100,000 neurons,” Palmeri says.

The National Eye Institute and the National Science Foundation supported the study.

Source: Vanderbilt University

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