autism

Kids with rewired brains read better

BrainRewiring2

Brain images of children between the ages of 8 and 10 show that the quality of white matter—the brain tissue that carries signals between areas of grey matter, where information is processed—improved substantially after the children received 100 hours of remedial training. The scan on the left shows the area of compromised white matter (blue area) among poor readers relative to good readers at the beginning of the study. Center scan shows the area where the structural integrity increased (red/yellow area) among poor readers who received instruction. Scan on the right shows that following instruction, there were no differences between the good and poor readers with respect to the integrity of their white matter.

CARNEGIE MELLON (US)—Intensive instruction to improve reading skills in young children actually causes the brain to physically rewire itself, creating new white matter that improves communication within the brain.

“Showing that it’s possible to rewire a brain’s white matter has important implications for treating reading disabilities and other developmental disorders, including autism,” says Marcel Just, the D.O. Hebb Professor of Psychology at Carnegie Mellon University and director of the Center for Cognitive Brain Imaging (CCBI).

As reported in the journal Neuron, brain images of children between the ages of 8 and 10 showed that the quality of white matter—the brain tissue that carries signals between areas of grey matter, where information is processed—improved substantially after the children received 100 hours of remedial training.

After the training, imaging indicated that the capability of the white matter to transmit signals efficiently had increased, and testing showed the children could read better.

Thomas Insel, director of the National Institute of Mental Health, agrees. “We have known that behavioral training can enhance brain function. The exciting breakthrough here is detecting changes in brain connectivity with behavioral treatment.

“This finding with reading deficits suggests an exciting new approach to be tested in the treatment of mental disorders, which increasingly appear to be due to problems in specific brain circuits,” Insel adds.

Just and coauthor Timothy Keller designed the study to discover what physically changes in the brains of poor readers who improve reading skills. They scanned the brains of 72 children before and after they went through a six-month remedial instruction program.

Using diffusion tensor imaging (DTI), a new brain imaging technique that tracks water movement in order to reveal the microscopic structure of white matter, the researchers found a brain change involving the white matter cabling that wires different parts of the brain together.

“Water molecules that are inside nerve fibers tend to move or diffuse parallel to the nerve fibers,” explains Keller, a research scientist at CCBI and author of the first developmental study of compromised white matter in autism.

“To track the nerve fibers, the scanner senses areas in which many water molecules are moving along in the same direction and produces a road-map of the brain’s wiring.”

Previous DTI studies had shown that both children and adults with reading difficulty displayed areas of compromised white matter.

The new study shows that 100 hours of intensive reading instruction improved children’s reading skills and also increased the quality of the compromised white matter to normal levels.

More precisely, the DTI imaging illustrated that the consistency of water diffusion had increased in this region, indicating an improvement in the integrity of the white matter tracts.

“The improved integrity essentially increases communication bandwidth between the two brain areas that the white matter connects, by a factor of 10,” Just says.

“This opens a new era of being able to see the brain wiring change when an effective instructional treatment is applied.  It lets us see educational interventions from a new perspective.”

Out of the 72 children, 47 were poor readers and 25 were reading at a normal level. The good readers and a group of 12 poor readers did not receive the remedial instruction, and their brain scans did not show any changes.

“The lack of change in the control groups demonstrates that the change in the treated group cannot be attributed to naturally occurring maturation during the study,” Keller explains.

Keller and Just also found that the amount of change in diffusion among the treated group was directly related to the amount of increase in phonological decoding ability.

The children who showed the most white matter change also showed the most improvement in reading ability, confirming the link between the brain tissue alteration and reading progress.

Additional analyses indicated that the change resulted from a decrease in the movement of water perpendicular to the main axes of the underlying white matter fibers, a finding consistent with increased myelin content in the region.

Although the authors caution that further research will be necessary to uncover the precise mechanism for the change in white matter, some previous findings indicate a role for electrical activity along axons in promoting the formation of myelin around them, providing a plausible physiological basis for intensive practice and instruction increasing the efficiency of communication among brain areas.

“We’re excited about these results,” Just says. “The indication that behavioral intervention can improve both cognitive performance and the microstructure of white matter tracts is a breakthrough for treating and understanding development problems.”

The research was funded by grants from the Richard King Mellon Foundation and the National Institute of Mental Health.

Carnegie Mellon news: www.cmu.edu/news

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