A single dose of the human papillomavirus vaccine is highly effective, a randomized controlled trial of 2,275 women in Kenya shows.
The current standard for women is a three-dose regimen.
The findings could help the World Health Organization reach its goal to have 90% of 15-year-old girls vaccinated against HPV by 2030, says Ruanne Barnabas, a professor of global health at the University of Washington School of Medicine at the time of the study. “The single-dose efficacy was the same as multiple doses.”
Currently, just 15% of women worldwide are vaccinated against HPV.
“These findings are a game-changer that may substantially reduce the incidence of HPV-attributable cervical cancer and positions single-dose HPV vaccination as a high-value and high-impact public health intervention that is within reach for us,” says Sam Kariuki, acting director general at the Kenya Medical Research Institute, where the study took place.
Worldwide, cervical cancer kills a woman every two minutes.
The findings add further support to the adoption of a single-dose HPV vaccine, which could increase accessibility in low- and middle-income countries, says Peter Dull, deputy director of vaccine development and surveillance at the Bill & Melinda Gates Foundation, which funded the study.
“HPV vaccines are a powerful tool to reduce cervical cancer, but too many women and girls in low- and middle-income countries don’t have access to them,” Dull says. “The KEN-SHE study results contribute to a growing body of evidence supporting the potential for a single-dose HPV vaccination.”
Most sexually active women and men will be infected with HPV at some point in their lives and some will be repeatedly infected. The peak time for acquiring infection among both women and men is shortly after becoming sexually active.
While nine out of 10 HPV infections resolve on their own in two years, others lead to cancer of the reproductive system, mainly cervical cancer. HPV also can cause cancers of the cervix, vagina, vulva, penis, and oropharyngeal cancer (throat, tongue, and tonsils).
Worldwide, cervical cancer kills a woman every two minutes. Most of those deaths are in Africa, which bears 80% of the cervical cancer burden. However, due to cost and limited vaccine supply, coverage has been low in areas with the highest cervical cancer burden.
In the trial, researchers randomly assigned women 15 to 20 years old a therapy and followed them from December 2018 to June 2021. To be eligible, the women needed to be sexually active, have no more than five lifetime partners, be HIV-negative, and have no history of HPV vaccination. Most of those who enrolled (57%) were between 15 and 17 years old and most reported only one lifetime sexual partner (61%).
The participants were randomized into three treatment arms:
- 760 received a bivalent vaccine that covered two strains of HPV (16/18), which represent 70% of cases.
- 758 received a nonavalent vaccine that covered seven strains of HPV (16/18/31/33/45/52/58), which represent 90% of cases.
- 757 received a vaccine that protects against meningococcal meningitis.
After 18 months, the bivalent vaccine was 97.5% effective against HPV 16/18 and the nonavalent vaccine was 97.5% effective against HPV 16/18. The nonavalent vaccine was 89% effective against HPV 16/18/31/33/45/52/58. Even if women tested positive for one strain of HPV, the vaccine protected them from other strains of the virus.
Researchers say more studies are needed to test how long the vaccine lasts.
“This trial brings new energy to the elimination of cervical cancer. It brings great hope to the women living in countries like Kenya, who have a high burden of the disease,” says Nelly Mugo, co-principal investigator on the study and senior principal clinical research scientist with the Center for Clinical Research at the Kenya Medical Research Institute in Nairobi. She also is an associate research professor of global health at the University of Washington.
Researchers say one impetus for the trial was the cervical cancer ward at the Kenyatta National Hospital in Nairobi. They say they want the ward empty.
“I believe that I will see cervical cancer eliminated in my lifetime,” says Maricianah Onono at the Kenya Medical Research Institute. “So, let’s do this—one shot for every woman!”
The “KEN-SHE” study is published in the journal NEJM Evidence.
Source: University of Washington
