How brain recalls what happened when

NYU (US) — New research showing how the brain remembers the order of events may offer a roadmap for addressing memory-related conditions like Alzheimer’s disease.

Previous research has shown the brain’s medial temporal lobe (MTL) has a significant role in declarative memory—that is, memory of facts and events or episodes—and damage to it causes impairment in memory for the timing of events within an episode.

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But little is still known about how individual structures within the MTL remember information about “what happened when” within a particular episode, for example the order of the toasts at a wedding reception or what preceded a game-winning hit in a baseball game.

For the new study, published in the journal Science, researchers ran animal subjects through a temporal-order memory task in which a sequence of two visual objects were presented and the subjects were required to retrieve that same sequence after a delay.

In order to perform the task correctly, the subjects needed to remember both the individual visual items (“what”) and their temporal order (“when”). During the experiment, the researchers monitored the activity of individual brain cells in the subjects’ MTL.

Results show that two main areas of the MTL are involved in integrating “what” and “when”:  the hippocampus and the perirhinal cortex.

The hippocampus, which is known to have an important role in a variety of memory tasks, provides an incremental timing signal between key events, giving information about the passage of time from the last event as well as the estimated time toward the next event.

The perirhinal cortex appeared to integrate information about what and when by signaling whether a particular item was shown first or second in the series.

“One of the Holy Grails of neuroscience is understanding exactly how our brains encode and remember episodic memories, including those of weddings, graduations, and other meaningful events in our lives,” says Wendy Suzuki, professor of neural science at New York University.

“These are rich memories that contain a lot of items with specific temporal contexts. We already knew the medial temporal lobe was critical for these complex memories, but what our new findings provide is insight into the specific patterns of brain activity that enables us to remember both the key events that make up our lives and the specific order in which they happened.”

The study was funded by grants from the National Institutes of Health.

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