AIDS

HIV cells’ secret hideout discovered

U. MICHIGAN (US)—HIV-infected cells lie in wait in hidden reservoirs, ready to jump on the chance to serve as a factory for new infection, a new study shows.

Researchers believe the findings, published online in Nature Medicine, indicate a new target for curing the disease.

“Antiviral drugs have been effective at keeping the virus at bay, says Kathleen Collins, associate professor of internal medicine, microbiology, and immunology at the University of Michigan. “However once the drug therapy is stopped, the virus comes back.”

In people infected with HIV (human immunodeficiency virus)—the virus that causes AIDS—there’s an unsolved problem with current antiviral drugs. Though life-saving, the drugs cannot root the virus out of the body.

Infected HIV cells are able to live undetected by the immune system, and provide the machinery for the virus to reproduce and spread, leading to the belief that they may lay-in-wait somewhere in the body.

Now researchers have discovered that bone marrow, previously thought to be resistant to the virus, can contain latent forms of the infection.

“This finding is important because it helps explain why it’s hard to cure the disease,” Collins says. “Ultimately to cure this disease, we’re going to have to develop specific strategies aimed at targeting these latently infected cells.

“Currently people have to take antiviral drugs for their entire life to control the infection,” she says.

Using tissue samples, HIV genomes in bone marrow were detected isolated from people effectively treated with antiviral drugs for more than six months.

While further studies are needed to demonstrate that stem cells can harbor the HIV virus, the study results confirm that HIV targets some long-lived progenitor cells, young cells that have not fully developed but mature into cells with special immune functions.

When active infection occurs the toxic effects of the virus kill the cell even as the newly made viral particles spread the infection to new target cells.

“Our finding that HIV infects these cells has clear ramifications for HIV disease because some of these cells may be long-lived and could carry latent HIV for extended periods of time,” she says. “These HIV cell reservoirs can be induced to generate new infections.”

The new research gives a broader view of how HIV overwhelms the body’s immune system and devastates its ability to regenerate itself.

Globally more than 30 million people are infected with HIV, including millions of children. Improvements have been made since the 1990s in the way the disease is treated that has led to an 85 percent to 90 percent reduction in mortality.

“Drugs now available are effective at treating the virus, making HIV more of a chronic disease than a death sentence,” Collins says.

“This has made a huge impact in quality of life, however only 40 percent of people worldwide are receiving antiviral drugs and unfortunately that means that not everybody is benefiting.”

University of Michigan news: www.ns.umich.edu/

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