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Genomes of ultra-social ants sequenced

NYU (US)—Scientists have at last sequenced the entire genome of two very different species of ant. The insights gleaned from the genetic blueprints are already yielding clues to their fascinating social behavior.

The work by researchers at New York University is detailed this week in the journal Science.

Comparing the two ant species—Jerdon’s jumping ant and the carpenter ant—scientists found that approximately 20 percent of their genes are unique, while some 33 percent are shared with humans.

Their complex social behavior, and their ability to be maintained in a laboratory, make them ideal species to study epigenetics—how genes are turned on or off in response to changing conditions rather than through alterations to actual sequences of DNA.

Epigenetics determine which genes are expressed in cells, thereby say distinguishing a nerve cell from a skin cell, and how modifications to gene expression can be passed on to future cell generations.

“Ants are extremely social creatures and their ability to survive depends on their community in a very similar way to humans,” says Danny Reinberg, professor of biochemistry at NYU Langone Medical Center. “Whether they are workers, soldiers or queens, ants seem to be a perfect fit to study whether epigenetics influences behavior and aging.”

Long live the queen
Reinberg has devoted most of his career to understanding the molecular machinery that determines how genes are turned on and off. He is especially interested in how epigenetics may influence longevity—in some ant colonies the queens live up to ten times longer than worker ants.

Although he was always fascinated by ants, it took years for the technology to catch up with the inspiration to study the interaction of epigenetics with longevity and behavior in these animals.

“In studying the genomes of these two ants, we were fascinated by the different behaviors and different roles that the worker ants develop,” says Reinberg. “Since every ant in the colony starts with the same genetic information, the different neuronal connections that specify the behavior appropriate for each social rank, must be controlled by epigenetic mechanisms.

“The findings could potentially help us learn more about the effect of epigenetics on brain function in humans.”

Researchers established that the carpenter ant genome has about 240 million bases and the jumping ant has approximately 330 million bases, about one-tenth of the human genome. Bases are the building blocks of DNA. They also found that the carpenter ant has 17,064 genes and the jumping ant has 18,564, compared to about 23,000 in humans.

Jumping ant
The jumping ant, or Harpegnathos saltator, lives in small colonies and when the queen dies, fighting erupts among workers, until a few prevail and become replacement queens. These new queens, or gamergates, actually live longer than their worker siblings.

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Above, a major worker of the carpenter ant Camponotus floridanus with its typically enlarged head. The species is a destructive pest in the Southeastern United States. (Credit: Jurgen Liebig)

In fact, Reinberg and his colleagues found an over-expression of proteins linked to longevity, including the enzyme telomerase, in these replacement queens. Interestingly, replacement queens also contained an abundance of small RNAs, short stretches of genetic material that fine tune gene expression in many organisms, including humans.

Carpenter ant
The carpenter ants, or Camponotus floridanus, have a far more sophisticated cast system and social organization. Only the queen lays fertilized eggs and when she dies, so does the colony.

Non-reproductive ants belong to two separate castes, major and minor workers. Major workers protect the colony, while minor workers forage for food. Even though these two types of worker ants begin life remarkably similar, epigenetics sculpt their brains and behaviors in different ways leading to their specialized tasks.

Genes and behavior
Comparing major and minor workers, researchers discovered large differences in the expression of genes that function in the brain, a small but important step toward understanding how genes influence behavior in ants.

“After the honey bee, ants are the second family of social insects to have their genome sequenced,” says NYU biochemist Roberto Bonasio, a study coauthor. “The next challenge is to start manipulating the genome of ants so that we can learn the function of specific genes related to aging and behavior.”

Researchers from Arizona State University and the University of Pennsylvania collaborated on the project. The genome sequencing was performed in collaboration with the Beijing Genomic Institute in Shenzhen, China.

More medical news from NYU: www.med.nyu.edu/

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