Fiber may raise risk of intestinal disease

UNC-CHAPEL HILL (US) — Eating a high fiber diet does not lower the risk of developing a disease of the large intestine, according to a new study that finds the opposite appears to be true.

Diverticulosis—in which pouches develop in the colon wall—affects about one-third of adults over age 60 in the United States. Although most cases are asymptomatic, when complications develop they can be severe, resulting in infections, bleeding, intestinal perforations, and even death. Health care associated with such complications costs an estimated $2.5 billion per year.

Published in the journal Gastroenterology, the study also counters the commonly-held belief that constipation increases a person’s risk of the disease.


“Despite the significant morbidity and mortality of symptomatic diverticulosis, it looks like we may have been wrong, for decades, about why diverticula actually form,” says lead researcher Anne Peery, a fellow in the gastroenterology and hepatology division at the University of North Carolina at Chapel Hill.

“While it is too early to tell patients what to do differently, these results are exciting for researchers. Figuring out that we don’t know something gives us the opportunity to look at disease processes in new ways.”

Since the late 1960s, doctors have recommended a high-fiber diet to regulate bowel movements and reduce the risk of diverticulosis. This recommendation is based on the idea that a low fiber diet will cause constipation and in turn generate diverticula as a result of increased pressure in the colon. However, few studies have been conducted to back up that assumption.

“Our findings dispute commonly held beliefs because asymptomatic diverticulosis has never been rigorously studied,” says Peery.

The UNC study is based on data from 2,104 patients aged 30-80 years who underwent outpatient colonoscopy from 1998-2010. Participants were interviewed about their diet, bowel movements, and level of physical activity.

“We were surprised to find that a low-fiber diet was not associated with a higher prevalence of asymptomatic diverticulosis,” Peery says. In fact, the study found those with the lowest fiber intake were 30 percent less likely to develop diverticula than those with the highest fiber intake.

The study also found constipation was not a risk factor and that having more frequent bowel movements actually increased a person’s risk. Compared to those with fewer than seven bowel movements per week, individuals with more than 15 bowel movements per week were 70 percent more likely to develop diverticulosis.

The study found no association between diverticulosis and physical inactivity, intake of fat, or intake of red meat. The disease’s causes remain unknown, but the researchers believe gut flora may play a role.

More research is needed before doctors change dietary recommendations, but the study offers valuable insights on diverticulosis risk factors, Peery says.

“At this time, we cannot predict who will develop a complication, but if we can better understand why asymptomatic diverticula form we can potentially reduce the population at risk for symptomatic disease.”

The research was supported by grants from the National Institutes of Health.

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