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"This is a type of decision-making that many of us grapple with in daily life, particularly the very young, the very old, and those with brain disease," says Yogita Chudasama. (Credit: Betsy Weber/Flickr)


Brain regions cooperate to put off a reward

New research with rats demonstrates that the hippocampus—associated with memory—and the nucleus accumbens—associated with pleasure—work together to make critical decisions that call for delayed gratification.

The researchers show that when these two structures were effectively “disconnected” in the brain, there is a disruption of decisions related to delayed gratification.

The findings, published in the European Journal of Neuroscience, have implications not only for a range of neuropsychiatric disorders such as ADHD, eating disorders, and anxiety disorders, but also for more common problems involving maladaptive daily decisions about drug or alcohol use, gambling, or credit card binges.

“This is a type of decision-making that many of us grapple with in daily life, particularly the very young, the very old, and those with brain disease,” says lead researcher Professor Yogita Chudasama of McGill University’s psychology department.

Sugar pellets

The researchers discovered the importance of this connection by working with rats trained to make choices between stimuli that would result in their receiving different amounts of rewards, after varying periods of time.

The rats were asked to choose between two identical visual shapes by pressing their nose against one of them on a touchscreen (similar to an iPad), in exchange for rewards in the form of sugar pellets. Like most humans, rats have a sweet tooth.

With time, rats learned to negotiate a trade-off between a small reward (1 sugar pellet) delivered immediately and a large reward (4 sugar pellets) delivered after a delay. The researchers discovered that the average rat, like the average human, is willing to wait a bit for a larger reward, but only for a certain period of time, and only if the reward is large enough.

Targets for therapy?

However, following disruption of the circuit connecting the hippocampus and nucleus accumbens, the rats became impatient and unwilling to wait, even for a few seconds. They always selected the immediate reward despite its smaller size.

Importantly, lesions to other parts of the brain, including the prefrontal cortex, known to be involved in certain aspects of decision-making, did not cause this behavioral change.

“In some ways this relationship makes sense; the hippocampus is thought to have a role in future planning, and the nucleus accumbens is a “reward” center and a major recipient of dopamine, a chemical responsible for transmitting signals related to pleasure and reward, but we couldn’t have imagined that the results would be so clear,” says Chudasama.

“In addition to providing a deeper understanding of decision-making, our results highlight the potential of this circuit, involving the hippocampus and nucleus accumbens, to be a therapeutic target in human patient groups.”

Source: McGill University

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