PENN STATE (US) — Feeding mice cocoa powder lowers inflammation, a condition linked to obesity and diseases such as diabetes.
Mice that were fed the human equivalent of 10 tablespoons of cocoa powder—about four or five cups of hot cocoa—during a 10-week period experienced less obesity-related inflammation than mice fed the same high-fat diet without the supplement.
“What surprised me was the magnitude of the effect,” says Joshua Lambert, associate professor of food science at Penn State. “There wasn’t as big of an effect on the body weight as we expected, but I was surprised at the dramatic reduction of inflammation and fatty liver disease.”
While researchers have linked obesity-related chronic inflammation to several diseases, including type 2 diabetes and fatty liver disease, the reason for the inflammation response is not completely known. (Credit: “cocoa and spoon” via Shutterstock)
Several indicators of inflammation and diabetes in the mice that were fed the cocoa supplement were much lower than the mice that were fed the high-fat diet without the cocoa powder and almost identical to the ones found that were fed a low-fat diet in the control group.
For example, they had about 27 percent lower plasma insulin levels than the mice that were not fed cocoa. High levels of insulin can signal that a patient has diabetes.
The cocoa powder supplement also reduced the levels of liver triglycerides in mice by a little more than 32 percent, says Lambert, who worked with Yeyi Gu, graduate student in food science, and Shan Yu, a graduate student in physiology. Elevated triglyceride levels are a sign of fatty liver disease and are related to inflammation and diabetes.
The mice also saw a slight but significant drop in the rate of body weight gain, according to the researchers, who reported their findings in the online version of the European Journal of Nutrition.
While researchers have linked obesity-related chronic inflammation to several diseases, including type 2 diabetes and fatty liver disease, the reason for the inflammation response is not completely known.
Two theories on inflammation and obesity that have emerged may help explain cocoa’s role in mitigating inflammation. In one theory, excess fat may activate a distress signal that causes immune cells to become activated and cause inflammation. The cocoa may reduce the precursors that act as a distress signal to initiate this inflammatory response.
Another theory is that excess fat in the diet interferes with the body’s ability to keep a bacterial component called endotoxin from entering the bloodstream through gaps between cells in the digestive system—gut barrier function—and alerting an immune response. The cocoa in this case may help improve gut barrier function.
Cocoa, although commonly consumed in chocolate, actually has low-calorie content, low-fat content and high-fiber content.
“Most obesity researchers tend to steer clear of chocolate because it is high in fat, high in sugar, and is usually considered an indulgence,” Lambert says. “However, cocoa powder is low in fat and low in sugar. We looked at cocoa because it contains a lot of polyphenolic compounds, so it is analogous to things like green tea and wine, which researchers have been studying for some of their health benefits.”
Lambert says future research will be conducted to better identify why the cocoa powder is effective in treating inflammation, as well as determine if the treatment is suitable for humans.
The National Institutes of Health supported this work.
Source: Penn State