aging

Childhood abuse may lead to early aging

Telomere_caps

Researchers have determined that children who suffer physical or emotional abuse may be faced with accelerated cellular aging as adults with an accelerated reduction in the size of telomeres, the “caps” on the end of chromosomes that promote cellular stability. Telomeres typically shorten with age. Above, human chromosomes (grey) capped by telomeres (white). (Courtesy: U.S. Department of Energy Human Genome Program)

BROWN (US)—Children who suffer physical or emotional abuse may be at greater risk of developing a variety of aging-related medical conditions as adults, including cardiovascular disease and cancer.

A new study by researchers at Brown University and  Butler Hospital shows that adults who report having been abused as children showed an accelerated reduction in the size of telomeres, the “caps” on the end of chromosomes that promote cellular stability. Telomeres typically shorten with age.

“It tells us something. It gives us a hint that early developmental experiences may have profound effects on biology that can influence cellular mechanisms at a very basic level,” says Audrey Tyrka, assistant professor of psychiatry and human behavior at the Warren Alpert Medical School of Brown University, and the study’s lead author.

The findings are published online in the journal Biological Psychiatry.

Scientists looked at 22 women and nine men between ages 18 and 64. Some of the subjects had no history of childhood maltreatment, but others said they had endured either moderate or severe mistreatment as children.

The adults who endured mistreatment as children varied in terms of the type of trauma they reported. They suffered individually from emotional abuse, emotional neglect, physical neglect, physical abuse and sexual abuse.

After measuring DNA extracted from blood samples of the 31 adults, researchers found accelerated shortening of telomeres in those who reported suffering maltreatment as children, compared to study participants who did not.

The work builds on previous research that established psychological stress and trauma as risk factors for a number of medical and psychiatric illnesses.

Other work has linked some of these psychiatric and medical problems with shortened telomere length. This study now establishes a link between early psychosocial stress and shorter telomere length.

Researchers have also found that telomeres shorten at a higher rate when exposed to toxins, such as radiation or cigarette smoke.

Other studies have looked at adult female caregivers who are responsible for children with developmental delays, determining a link between accelerated telomere shortening and the higher stress levels the caregivers faced.

This may be the first attempt to look at telomere length in relation to childhood mistreatment.

Researchers said the early findings are compelling, because they looked at adults who were otherwise healthy and had not had any current or past psychiatric disorders. The early data shows strong links between childhood stress and the accelerated shortening of telomeres.

More work is needed, Tyrka says. “We don’t know what the full implications of this are yet. Shorter telomere lengths are linked to aging and certain diseases, so it is possible that this is a mechanism of risk for illness following childhood abuse,” she explains.

“But the precise role of telomeres in this process remains to be determined.”

Grants from the National Institute of Mental Health and the National Institute of Neurological Disorders funded the study.

Brown University news: http://news.brown.edu

Related Articles