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Can’t beat a cold? DNA ‘caps’ may be why

CARNEGIE MELLON (US) — A biological marker in the immune system associated with aging may also predict as early as age 22 our ability to fight off the common cold.

A new study finds that the length of telomeres—protective cap-like protein complexes at the ends of chromosomes—predict resistance to upper respiratory infections in young and midlife adults. Telomeres shorten as we get older—as a cell’s telomeres shorten, it loses its ability to function normally and eventually dies.

Having shorter telomeres is associated with early onset of aging related diseases such as cardiovascular disease and cancer, and with mortality in older adults. Unknown until now is whether telomere length plays a role in the health of young to midlife adults.

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“Our work suggests the possibility that telomere length is a relatively consistent marker across the life span and that it can start predicting disease susceptibility in young adulthood,” says Sheldon Cohen, professor of psychology at Carnegie Mellon University.

“We knew that people in their late 50s and older with shorter telomeres are at a greater risk for illness and mortality. We also knew that factors other than aging, such as chronic stress and poor health behaviors, are associated with shorter telomeres in older people. Consequently, we expected that younger people would vary in their telomere length as well and wanted to see what this would mean for their health.”

For the study, published in the Journal of the American Medical Association, Cohen and his team measured the telomere length of white blood cells from 152 healthy volunteers aged 18-55. These individuals were then exposed to a rhinovirus, which causes a common cold, and quarantined for five days to see if they actually developed an infection.

The results showed that participants with shorter telomeres were more likely to become infected by the cold virus. Further, although there was no relationship between telomere length and infection among the youngest participants (ages 18-21), beginning at about age 22, telomere length started to predict whether individuals would develop an infection. As participant age increased, telomere length became an even stronger predictor.

Additionally, telomere length of a specific type of white blood cell—a CD8CD28- T-cytolytic cell—was a superior predictor of infection and cold symptoms than other white blood cell types. The telomeres found in CD8CD28- cells shorten more quickly than those found in other cell types, and previous research has found shorter telomere length in these cells to be associated with decreases in markers of immune competence.

“These cells are important in eliminating infected cells and those with shorter telomeres in the CD8CD28- cell population may be at greater risk for infection because they have fewer functional cells available to respond to the (cold) virus,” Cohen says.

“The superior ability of CD8CD28- T-cytolytic cells to predict infection gives us an idea of which cells to focus on in future work on how telomere length influences the immune system’s response to infection and other immune-related challenges.

“The increased importance of telomere length with age is likely because the younger participants had fewer very short telomeres, or that their young immune systems were able to compensate for the loss of effective cells.”

The work is preliminary, Cohen says, “and further work with other viruses and with natural infections will help clarify its implications.”

Researchers from the University of Virginia, University of Pittsburgh, and the University of California, San Francisco contributed to the study, which was funded by the National Center for Complementary and Alternative Medicine and the National Institute of Allergy and Infectious Diseases, the MacArthur Foundation, the Eberly Foundation, the Hamburg Fellowship, and National Institutes of Health.

Source: Carnegie Mellon University

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