Bringing home baby and chronic health risks

YALE (US)—New research suggests pregnancy complications may have a long-term effect on a woman’s health and may increase the risk for difficulties with future pregnancies.

“Pregnancy acts like a natural stress test for women,” sayss Michael Paidas, associate professor and codirector of Yale Women and Children’s Center for Blood Disorders.

One of two studies conducted by researchers at Yale School of Medicine showed that women who have had two pregnancies complicated by preeclampsia are at a higher risk of hypertension after pregnancy.

“While delivery may ‘cure’ preeclampsia in the moment, these mothers are at high risk of chronic hypertension, type 2 diabetes mellitus, and blood clots for the rest of their lives,” adds Paidas.

Working in collaboration with the University of Copenhagen in Denmark, senior author Paidas and his team conducted a retrospective study of more than 11 million women who gave birth in Denmark from 1978 to 2007.

Findings, published in the June issue of the journal Hypertension, show that among women with preeclampsia, a complication of pregnancy linked to life-threatening cardiovascular disease, the risks of subsequent hypertension risks were compounded with each affected pregnancy. Only healthy women without any other previously identified medical problems were included in the study.

“The only reliable treatment for preeclampsia is delivery of the baby,” says Paidas, who emphasizes the research adds to growing data on the link between hypertensive pregnancy disorders, diabetes, cardiovascular disease, and maternal death.

Paidas and the research team are conducting ongoing studies to explore the genetic links between pregnancy complications, cardiovascular disease, and diabetes.

“Physicians and other healthcare professionals should be encouraged to include the history of a woman’s pregnancy outcomes when estimating the risk of cardiovascular disease,” he says.

In light of this new information, Paidas also urges care providers to exercise caution when prescribing oral contraceptives to women with hypertensive pregnancy complications.

“Identifying women soon after a hypertensive pregnancy will alert care providers to the increased risks of heart disease, diabetes, and blood clotting and allow prompt intervention.”

In a second study published in the June issue of the journal Obstetrics & Gynecology, using the same Danish registry, Paidas and his team found that preterm delivery, preeclampsia, and low-birth weight tend to recur and predispose to each other in a second pregnancy. The severity of the complication in the first pregnancy further increases these risks.

For example, women whose first delivery occurred full term had a 2.7 percent risk for having a preterm delivery in the second pregnancy. However, if their first pregnancy resulted in a delivery between 32 and 36 weeks of gestation, the risk of a preterm delivery in the second pregnancy increased to 14.7 percent.

Similarly, if their first pregnancy resulted in an even earlier preterm delivery—between 28 and 32 weeks of gestation—the risk of a preterm delivery in the second pregnancy increased to 25.4 percent. Delivery between 20 and 27 weeks in the first pregnancy doubled the risk for delivering a baby that was small for gestational age in the second pregnancy.

“Our data from this study suggest that spontaneous preterm delivery, preeclampsia, low fetal growth, placental abruption, and stillbirth in a first and second pregnancy are interrelated,” says Paidas.

“Perhaps they all may be features of a ‘placenta-associated syndrome.’ Healthy women with a significant pregnancy complication that is considered part of the placenta-associated syndrome are vulnerable in the second pregnancy. Therefore care providers should tailor surveillance, prevention, and/or treatment interventions in these patients.”

Researchers from Rigshospitalet in Copenhagen and the University of Cincinnati College of Medicine contributed to the studies.

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