Obesity and type 2 diabetes harm bone health, according to a new study with rats that suggests exercise can prevent the damage.
“Researchers once thought obesity was protective of bone because with more body mass, individuals have more bone mass; more bone mass typically decreases risk of osteoporosis and associated fractures,” says Pam Hinton, associate professor of nutrition and exercise physiology at the University of Missouri.
“What we’ve come to realize is that the bone of people with obesity and type 2 diabetes isn’t good, quality bone. These individuals have an increased risk of fractures, so that extra body weight isn’t protective.”
Researchers examined how the development of obesity and type 2 diabetes affect bone structure, formation, and strength over time. Specifically, they studied the bones of rats that had a predisposition to overeat, which caused them to gain weight and become insulin resistant. This pattern of weight gain and insulin resistance parallels the development of obesity and type 2 diabetes in humans, Hinton says.
For the study, published in the journal Metabolism, half the rats were allowed to overeat and voluntarily exercise on running wheels; the other rats programmed to overeat remained sedentary. The researchers also had a control group of non-overeating rats that remained sedentary.
The researchers studied bones from rats in the three groups at different ages to determine how early in the development of obesity and diabetes the bone was affected negatively.
“As the rats continued to grow, all groups increased their bone mass, but the rats that were obese and sedentary didn’t accumulate as much bone mass relative to their body weight,” Hinton says. “So, decreased bone formation, loss of bone mass, and decreased bone strength all were present in the obese, diabetic, sedentary rats. However, the rats that exercised did not lose bone strength. In fact, the rats that ran on the wheels had stronger bones than the normal-weight controls.”
This study doesn’t explain how exercise increases bone quality, Hinton says. The animals in the exercise group were healthier; they didn’t develop the same insulin resistance and diabetes, which might explain why the bones of the exercising rats were healthier.
“Once we can identify why bones in individuals with obesity and type 2 diabetes are weaker and how they become weaker, we can start developing more treatments through lifestyle and behavioral changes.”
The Harry S Truman Memorial Veterans Hospital in Columbia, a VA Career Development Award, and the Department of Nutrition and Exercise Physiology supported the work.
Source: University of Missouri