Inflammation from high BMI may damage brain

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Having a higher body mass index, or BMI, can negatively impact cognitive functioning in older adults, say researchers, who suggest inflammation is to blame.

“The higher your BMI, the more your inflammation goes up,” says Kyle Bourassa, a psychology doctoral student at the University of Arizona. “Prior research has found that inflammation—particularly in the brain—can negatively impact brain function and cognition.”

Previous studies also have linked higher BMI—an index of body fat based on height and weight—to lower cognitive functioning. But how and why the two are connected has been far less clear.

“We saw this effect, but it’s a black box. What goes in between?” says Bourassa, lead author of a new study in the journal Brain, Behavior and Immunity. “Establishing what biologically plausible mechanisms explain this association is important to be able to intervene later.”

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Bourassa and coauthor David Sbarra, professor of psychology, analyzed data from the English Longitudinal Study of Aging, which includes over 12 years’ worth of information on the health, well-being, and social and economic circumstances of the English population age 50 and older.

Using two separate samples from the study—one of about 9,000 people and one of about 12,500—researchers looked at aging adults over a six-year period. They had information on study participants’ BMI, inflammation and cognition, and they found the same outcome in both samples.

“The higher participants’ body mass at the first time point in the study, the greater the change in their CRP levels over the next four years,” Bourassa says. “CRP stands for C-reactive protein, which is a marker in the blood of systemic inflammation in your body. Change in CRP over four years then predicted change in cognition six years after the start of the study. The body mass of these people predicted their cognitive decline through their levels of systemic inflammation.”

The findings support existing literature linking inflammation to cognitive decline and take it a step further by illuminating the important role of body mass in the equation, but Sbarra adds a word of caution in trying to understand the findings.

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“The findings provide a clear and integrative account of how BMI is associated with cognitive decline through systemic inflammation, but we need to remember that these are only correlational findings. Of course, correlation does not equal causation. The findings suggest a mechanistic pathway, but we cannot confirm causality until we reduce body mass experimentally, then examine the downstream effects on inflammation and cognition.”

“Experimental studies finding whether reducing inflammation also improves cognition would be the gold standard to establish that this is a causal effect,” Bourassa adds.

Cognitive decline is a normal part of aging, even in healthy adults, and can have a significant impact on quality of life. The current research may provide valuable insights for possible interventions and new research directions in that area.

“If you have high inflammation, in the future we may suggest using anti-inflammatories not just to bring down your inflammation but to hopefully also help with your cognition,” Bourassa says.

Of course, maintaining a healthy weight is also good for overall health. “Having a lower body mass is just good for you, period. It’s good for your health and good for your brain.”

Source: University of Arizona