Bacteria ‘talk’ and plants listen

UC DAVIS (US) — Scientists have discovered a new signal that helps invading bacteria communicate at the same time it helps targeted rice plants coordinate defensive attacks on the disease-causing invaders.

The finding could lead to new methods of combating infection not just in plants, but in humans.

“Just as invading armies often use coded messages to coordinate attacks on their targets, so single-celled bacteria use biological signals to communicate when they attack plants and animals,” says Pamela Ronald, a professor of plant pathology at the University of California, Davis and the lead researcher on the study.

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“Scientists have known this for 20 years, however results from our study reveal a type of bacterial signal that has never been described before.”

Researchers are using molecular biology to better understand how to improve the hardiness and yield of rice, a staple food for more than half of the world’s population and an important model for plant research.

Up until now, scientists thought that two major groups of bacteria used two distinctly different types of communication codes, Ronald says. However Ax21, the small protein examined in this study, doesn’t fit into either of those previously identified communication codes.

Ax21 is made inside the bacterial cell and processed to generate a shorter signal that is secreted outside the bacterium. This signal tips off other bacteria to assemble themselves into elaborate protective bunkers, called biofilms, which make the bacteria resistant to drying out and antibiotic treatment.

“Additionally, Ax21 triggers a change in the expression of nearly 500 bacterial genes, transforming the bacteria from fairly benign organisms into fierce invaders,” Ronald says.

“In essence, through communication and communal living, the bacteria increase their chances of survival and proliferation,” she says, noting that in rice, the bacteria multiply rapidly in the arteries that transport water, causing the plant to wither and die.

While most rice plants have little defense against the Ax21-mediated bacterial attack, some rice plants carry an immune receptor called XA21 that detects the Ax21 protein produced by the invading bacteria. XA21 belongs to a large class of immune receptors in plants and animals.

The importance of these receptors in immunity is reflected in the awarding of the 2011 Nobel Prize in physiology and medicine to researchers Bruce Beutler of The Scripps Research Institute in La Jolla and Jules Hoffman of the National Center of Scientific Research in Strasbourg, France, for their discoveries of similar receptors in animals.

The new study, published in the journals PLoS One and Discovery Medicine, points out that the Ax21 signaling protein triggers the XA21 immune receptor to biologically alert the plant to launch a powerful defense response against the invading bacteria.

The researchers also demonstrated that Ax21 is present in a human disease-causing bacterium that is known to infect hospital patients.

“This study demonstrates that bacteria communicate using private messages. However, plants can intercept these messages and gain a tactical advantage in the evolutionary battle,” Ronald says. ” It’s a fascinating story.”

Researchers from Kyung Hee University in Korea contributed to the study that received funding from the U.S. Department of Agriculture and the National Institutes of Health.

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