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The result of these experiments is a set of instructions that can be incorporated into a robotic prosthetic arm to provide sensory feedback to the brain through a neural interface. Sliman Bensmaia believes such feedback will bring these devices closer to being tested in human clinical trials. (Credit: PNAS)

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Amputees may feel ‘touches’ with limbs linked to brain

A recent series of experiments with monkeys marks a step toward developing touch-sensitive prosthetic limbs that interface directly and in real-time with the brain.

“To restore sensory motor function of an arm, you not only have to replace the motor signals that the brain sends to the arm to move it around, but you also have to replace the sensory signals that the arm sends back to the brain,” says Sliman Bensmaia, an assistant professor at the University of Chicago and senior author of the study published in the Proceedings of the National Academy of Sciences.

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“We think the key is to invoke what we know about how the brain of the intact organism processes sensory information, and then try to reproduce these patterns of neural activity through stimulation of the brain,” adds Bensmaia.

Bensmaia’s research is part of Revolutionizing Prosthetics, a multi-year Defense Advanced Research Projects Agency (DARPA) project. The goal is to create a modular, artificial upper limb that will restore natural motor control and sensation in amputees.

Managed by the Johns Hopkins University Applied Physics Laboratory, the project has brought together an interdisciplinary team of experts from academic institutions, government agencies, and private companies.

Sensing touch

Bensmaia and his colleagues at the University of Chicago are working specifically on the sensory aspects of these limbs. In a series of experiments with monkeys, whose sensory systems closely resemble those of humans, they identified patterns of neural activity that occur during natural object manipulation and then successfully induced these patterns through artificial means.

The first set of experiments focused on contact location, or sensing where the skin has been touched. The animals were trained to identify several patterns of physical contact with their fingers. Researchers then connected electrodes to areas of the brain corresponding to each finger and replaced physical touches with electrical stimuli delivered to the appropriate areas of the brain.

The animals responded the same way to artificial stimulation as they did to physical contact.

Sensing pressure

Next the researchers focused on the sensation of pressure. In this case, they developed an algorithm to generate the appropriate amount of electrical current to elicit a sensation of pressure. Again, the animals’ response was the same whether the stimuli were felt through their fingers or through artificial means.

Finally, Bensmaia and his colleagues studied the sensation of contact events. When the hand first touches or releases an object, it produces a burst of activity in the brain. Again, the researchers established that these bursts of brain activity can be mimicked through electrical stimulation.

The result of these experiments is a set of instructions that can be incorporated into a robotic prosthetic arm to provide sensory feedback to the brain through a neural interface. Bensmaia believes such feedback will bring these devices closer to being tested in human clinical trials.

“The algorithms to decipher motor signals have come quite a long way, where you can now control arms with seven degrees of freedom. It’s very sophisticated. But I think there’s a strong argument to be made that they will not be clinically viable until the sensory feedback is incorporated,” Bensmaia says. “When it is, the functionality of these limbs will increase substantially.”

The Defense Advanced Research Projects Agency, National Science Foundation, and National Institutes of Health funded this study.

Source: University of Chicago

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