Addicts may have glitch in frontal brain

UC BERKELEY (US) — Neuroscientists have pinpointed the exact locations in the brain where calculations are made that can result in addictive behaviors, like those linked to drugs, overeating, and gambling.

“The better we understand our decision-making brain circuitry, the better we can target treatment, whether it’s pharmaceutical, behavioral, or deep brain stimulation,” says Jonathan Wallis, associate professor of psychology and neuroscience at University of California, Berkeley.

Wallis says he was inspired to study the brain mechanism behind substance abuse after observing the lengths to which an addict will go to fulfill a craving, despite knowing the downside of a habit. He wanted to know what the drug did to the brain that made it so difficult to not make the right choice and what prevented the addict from making a healthier one.


In the new study, published in Nature Neuroscience, Wallis targeted the orbitofrontal cortex and anterior cingulate cortex—two areas in the frontal brain—because previous research has shown that patients with damage to these areas of the brain are impaired in the choices they make.

While these individuals may appear perfectly normal on the surface, they routinely make decisions that create chaos in their lives. A similar dynamic has been observed in chronic drug addicts, alcoholics, and people with obsessive-compulsive tendencies.

“They get divorced, quit their jobs, lose their friends, and lose all their money,” Wallis says. “All the decisions they make are bad ones.”

To test the hypothesis that these areas of the brain are the key players in impaired decision-making, researchers measured the neural activity of macaque monkeys as they played games in which they identified the pictures most likely to deliver juice through a spout into their mouths.

The animals quickly learned which pictures would most frequently deliver the greatest amount of juice, allowing researchers to see what calculations they were making, and in which part of the brain. The brains of macaques function similarly to those of humans in basic decision making. The exercise was designed to see how the animals weigh costs, benefits, and risks.

The results show that the orbitofrontal cortex regulates neural activity, depending on the value or “stakes” of a decision. This part of the brain enables you to switch easily between making important decisions, such as what school to attend or which job to take, and making trivial decisions such as coffee versus tea or burrito versus pizza.

But in the case of addicts and people with damage to the orbitofrontal cortex, the neural activity does not change based on the gravity of the decision, presenting trouble when these individuals try to get their brains in gear to make sound choices, the findings suggest.

As for the anterior cingulate cortex, the study found that when this part of the brain functions normally, we learn quickly whether a decision we made matched our expectations. If we eat food that makes us sick, we don’t eat it again. But in people with a malfunctioning anterior cingulate cortex, these signals are missing, and so they continue to make poor choices, Wallis says.

“This is the first study to pin down the calculations made by these two specific parts of the brain that underlie healthy decision-making,”  Wallis says, who believes that a clearer understanding of how people with addictions make decisions may help remove some of the stigma of the condition.

However, Wallis warned that the findings should not be used as a rationale for addicts to maintain unhealthy habits. Chronic drug and alcohol use changes the brain circuitry, and that can lead to unhealthy choices, he says.

If anything, the findings offer hope that, through understanding the mechanism of addiction, treatment can be targeted at these risk-weighing, decision-making centers of the brain.

“We know beyond doubt that addiction is a complex brain disease with significant behavioral characteristics,” says Susan E. Foster, vice president and director of policy research and analysis at the National Center on Addiction and Substance Abuse at Columbia University.

“This research is an important contribution to understanding how the disease works. The challenge going forward is to sharpen our understanding, translate this knowledge into effective medical treatments and new prevention strategies and ultimately find a cure for this disease.”

Researchers from the University of London and the University of Oxford contributed to the study that was funded by the National Institute on Drug Abuse.

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