About one percent of the world’s population stutters, a speech disorder that affects four times as many men as women.
Researchers at the University of California, Santa Barbara, have published two studies: one that identifies brain structures linked to stuttering and another that examines a new way to treat the condition.
According to Janis Ingham, a professor emerita of speech and hearing sciences and coauthor of both papers, the two studies taken together demonstrate two critical points: a neuroanatomic abnormality exists in the brains of people who stutter, yet they can learn to speak fluently in spite of it.
The biology of stuttering
What causes stuttering in the first place? Once treated as a psychological or emotional condition, stuttering can now be traced to brain neuroanatomy and physiology, according to the researchers.
“We’re one of a number of groups making a strong case that there is something fundamentally different about the brains of people who stutter,” says Professor Scott Grafton, who led the study.
Researchers used diffusion spectrum imaging (DSI) in an MRI scanner to examine the white matter in the brains of eight adult stutterers.
DSI parses tracts in the brain and follows them beyond the point where they intersect.
Grafton likens the brain’s tracts to highways and surface streets, only in the brain the intersections are three-dimensional.
Grafton and Matt Cieslak, a graduate student in Grafton’s lab, discovered abnormalities of the arcuate fasciculus, one of the key pathways that connect the language areas of the brain. So named because it forms an arch, the arcuate fasciculus connects at the front of the brain to the area of the cerebral cortex linked to speech production. At the back of the brain, it branches into three parts.
“What’s interesting is the back half,” says Grafton. “In the vast majority of the stutterers we scanned, there seems to be a large portion of the connection projecting into the temporal cortex, an area of the brain also critical for speech perception.
“Seven of eight subjects are missing this third branch of the arcuate fasciculus bundle. So in this small group, we can see a really, really strong effect.”
These results required not only sensitive imaging but also completely new analysis methods to examine each tract in the brain separately and at the individual subject level.
“Big advances have allowed us to reconstruct pathways with greater detail than we were able to do before,” says Cieslak, who developed the new analysis techniques and is lead author of the paper published in the Journal of Speech, Language, and Hearing Research.
“In terms of data, each subject produces what looks like a bowl of spaghetti or a ball of yarn and we had to figure out how to put that data into an analytical framework,” he explains. “About 40,000 lines of code later we now have a platform for analyzing white matter data, which can be expanded to a large set of subjects.”
New treatment and iPad app
A new approach to treat the condition teaches stutterers to prolong their speech. It’s called Modifying Phonation Intervals (MPI) Stuttering Treatment Program.
The intensive MPI program teaches stutterers to reduce the frequency with which they produce very short intervals of phonation while speaking.
A phonated interval is the elapsed time of a voiced unit of speech. In the word “shout,” for example, “out” is a voiced (phonated) unit; “sh” is an unvoiced unit. The MPI program software provides real-time feedback to the stutterer regarding the occurrence of these short phonated intervals so he or she can learn to reduce their occurrence, which improves fluency.
After a lengthy period of basic research and testing, the MPI program was studied in phase II clinical trials with funding from the National Institutes of Health. Roger Ingham and his colleagues found that reducing the frequency of the speaker’s short phonated intervals resulted in durable and natural-sounding fluent speech for the majority of study participants.
“It’s not a five-minute job,” says Ingham, lead author of the paper published in the American Journal of Speech-Language Pathology. “A person who stutters needs to be under this treatment system for two to three hours a day, six days a week for the first phase of the program, which lasts about three weeks.”
MPI treatment is divided into four phases, each designed to be managed jointly by the person who stutters and the clinician. MPI program software is available as an app for the iPad. The clinician uses a “master” app to teach the stutterer how to follow the program on an iPad at home.
Toastmasters and virtual reality
Progress is contingent on performance. Once participants complete the initial phase, they move on to increasingly complex speaking tasks until they ultimately conquer what they deem to be their most difficult speaking situations.
“We have to be extraordinarily creative in developing some of these situations,” Ingham says. “We’ve had participants talking before classes and being interviewed by UCSB’s Nobel Prize winners, but we also use Toastmasters where they get a lot of experience speaking in public.”
Ingham’s team is currently investigating the use of virtual reality in conjunction with the MPI treatment program. They are exploring whether those difficult speaking situations can be created more efficiently and effectively through reality versions.
The study results show that outcomes for the MPI and prolonged speech treatment groups were similar. However, more people in the MPI program were able to identify and employ the specific speech behaviors necessary for successful treatment.
Ingham notes that twice as many people receiving the MPI treatment were successful in maintaining naturally fluent speech 12 months after they finished the program compared to those receiving the prolonged speech treatment.
Going forward, the researchers would like to study the brains of recovered stutterers to see whether white matter actually changes with treatment.
“Is there something special in the wiring of people who recover?” Grafton asks. “Maybe they are missing part of the arcuate fasciculus pathway but they’ve got another one that’s strong enough to pick up the slack. We’d like to be able to investigate that possibility using DSI.”
“I’m really excited about this work because it’s transforming how we do research in patient groups with very common and challenging developmental disorders that have a great impact on people’s lives but are otherwise largely ignored in neuroscience and by funding agencies,” Grafton adds.
“They get diagnosed or described and we throw therapies at them but we don’t really understand the pathophysiologic basis or the biology of these problems. The fact that we can now see big changes in scans of individuals who stutter is huge.
“It opens up a lot of opportunities, not just for stutterers but for all kinds of developmental problem like dyslexia, childhood speech apraxia, and disorders of coordination.”
People who have or have had issues with stuttering and are interested in participating in ongoing brain scan studies should email Ingham at firstname.lastname@example.org.
Source: UC Santa Barbara