A chemical used to detect amyloid plaques in the brains of people with Alzheimer’s extends the lifespan of thousands of roundworms, a tightly replicated study shows.
In a study involving more than 44,000 animals published in Nature Communications, researchers tested 10 different compounds from multiple species of roundworms that featured more genetic diversity than can be found between mice and humans. Scientists found that Thioflavin T was the most effective of all drugs tested because it increased the lifespan in all species and doubled it in one.
“These worms may have been the same basic animal but, like humans, their genes had a lot of variation which means that they could have responded to interventions differently,” says Monica Driscoll, co-principal investigator and professor of molecular biology and biochemistry at Rutgers University.
Up until now, chemical compounds that have been found to extend life in worms and mice have been most often studied in animals with specific—and somewhat uniform—genetic backgrounds. But Thioflavin T worked in all the genetically diverse species, possibly by preventing damaged and misfolded proteins which in humans contributes to age-related diseases like Alzheimer’s, Parkinson’s, and Huntington’s.
“We found this one compound did have a positive effect on all the strains, which is important if you want to find the best candidate intervention for healthy aging across a large swath of the population.”
The scientific community has gotten criticism for spending money and conducting research that other laboratories cannot reproduce. A study published in PLOS Biology in 2015 estimated that $28 billion went to preclinical studies in which the findings made in one research study could not be reproduced in another.
“By documenting in unprecedented detail everything we do in the lab, we were able to get close to seeing identical results across three labs,” says Driscoll. Detailing how this work is done is just as important as our results.”
This is particularly important for aging research, Driscoll says, because the targeted outcome is not to just extend life but to increase the quality.
“In my opinion, the real goal of aging research should not be longevity at all but rather a person’s health span—how long they can maintain an active, disease free, high quality of life,” Driscoll says. “The greatest risk factor for diseases like diabetes, cancer, and neurodegenerative disease is age, so that is why research looking at delaying the onset of age-associated decline is so important.”
Source: Rutgers University