Posts Tagged ‘ubiquitin’
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This structural model shows a chain of nine ubiquitins, well above the threshold length of four or more required to tag a protein for degradation. Gaining insights into the ubiquitin system is important, says biologist Raymond Deshaies, because ubiquitin ligases play a critical role in a number of human diseases, including cancer, due to their role in the regulation of the cell cycle.(Credit: Caltech/Gary Kleiger)
CALTECH (US)—Researchers have been able to view in detail, and for the first time, the previously unexplained process by which long chains of a protein called ubiquitin are added to proteins that control the cell cycle. The finding may one day lead to the development of targeted cancer therapies. Continue…
