Memory keeps declining for years after stroke

"Stroke is common, costly, and disabling, and cognitive decline is a major cause of disability in stroke survivors," says Deborah Levine. "Yet cognitive decline after stroke has not received enough attention." (Credit: alan berning/Flickr)

A stroke happens in an instant, but memory and thinking ability can keep getting worse for as long as six years afterward—at a rate much faster than normal brain aging.

For a new study, researchers used data from 23,572 Americans aged 45 years or older from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.

“We found that stroke is associated with cognitive decline over the long-term,” says Deborah Levine, who holds faculty appointments in internal medicine and neurology at University of Michigan. “That is, survivors had accelerated and persistent declines in memory and thinking ability during the years after stroke—even after accounting for their cognitive changes before and early after the event.”

Persistent declines

Participants had no history of cognitive impairment when they entered the large population-based study in the mid-2000s. They had tests of their memory and thinking ability at the beginning of the study and at regular intervals during follow-up. They were monitored twice per year for acute stroke events; suspected strokes were confirmed by study physicians using medical records.

Over the next six to 10 years, 515 of them had a stroke, and researchers compared their test results with those from the 23,057 who remained stroke-free.

Because they had information on how stroke survivors’ memory and thinking ability changed over time before the stroke, researchers could separate the declines in brain function associated with aging from declines in brain function associated with stroke.

‘Common, costly, and disabling’

In their study, stroke was associated with declines in global cognition, new learning, and verbal memory early after stroke as well as accelerated and persistent declines in global cognition and thinking ability over the years after the event.

“Stroke is common, costly, and disabling, and cognitive decline is a major cause of disability in stroke survivors,” Levine says. “Yet cognitive decline after stroke has not received enough attention. We hope these findings will shine a spotlight on stroke survivors’ long-term cognitive needs.”

The findings, published in the Journal of the American Medical Association, suggest a need for better long-term follow-up care for the nation’s 7 million stroke survivors, including therapy to retain or even regain cognitive ability.

“Our results suggest that stroke survivors warrant monitoring for mounting cognitive impairment over the years after the event,” says Levine. “Health systems and payers will need to develop cost-effective systems of care that will best manage the long-term needs and cognitive problems of this growing and vulnerable stroke survivor population.

Long-term care

The findings also suggest that long-term cognitive ability could be a new marker for measuring the effects of therapies to treat the initial effects of stroke.


More research is needed to determine whether the acute and also accelerated long-term cognitive declines after stroke are the result of incomplete rehabilitation from the initial stroke, subsequent brain injury due to uncontrolled risk factors, behavioral changes, or other mechanisms, Levine says.

Researchers from University of Alabama at Birmingham and Indiana University are coauthors of the study. The National Institute for Neurological Disorders and Stroke and the National Institute on Aging funded the work.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the US Department of Veterans Affairs.

Source: University of Michigan