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Social change shows up in preteen brain

U. OREGON (US) — New research reveals which brain regions are active as kids on the brink of adolescence consider their identity and social status.

In a study of 27 neurologically typical children who underwent functional magnetic resonance imaging (fMRI) at ages 10 and 13, activity in the brain’s ventromedial prefrontal cortex increased dramatically when the subjects responded to questions about how they view themselves.

The findings, to appear in the April 24 issue of the Journal of Neuroscience, confirm previous findings that specific brain networks support self-evaluations in the growing brain, but, more importantly, provide evidence that basic biology may well drive some of these changes, says Jennifer H. Pfeifer, professor of psychology and director of the psychology department’s Developmental Social Neuroscience Lab at the University of Oregon.

“This is a longitudinal fMRI study, which is still relatively uncommon,” Pfeifer says. “It suggests a link between neural responses during self-evaluative processing in the social domain, and pubertal development. This provides a rare piece of empirical evidence in humans, rather than animal models, that supports the common theory that adolescents are biologically driven to go through a social reorientation.”

Participants were scanned for about seven minutes at each visit. They responded to a series of attributes tied to social or academic domains—social ones such as “I am popular” or “I wish I had more friends” and academic ones such as “I like to read just for fun” or “Writing is so boring.” Social and academic evaluations were made about both the self and a familiar fictional character, Harry Potter.

In previous research, Pfeifer had found that a more dorsal region of the medial prefrontal cortex was more responsive in 10-year-old children during self-evaluations, when they were compared to adults. The new study, she says, provides a more detailed picture of how the brain supports self-development by looking at change within individuals.

The fMRI analyses found it was primarily the social self-evaluations that triggered significant increases over time in blood-oxygen levels, which fMRI detects, in the ventral medial prefrontal cortex.

Additionally, these increases were strongest in children who experienced the most pubertal development over the three-year study period, for both girls and boys. Increases during academic self-evaluations were at best marginal. Whole-brain analyses found no other areas of the brain had significant increases or decreases in activity related to pubertal development.

“Neural changes in the social domain were more robust,” Pfeifer says. “Increased responses in this one region of the brain from age 10 to 13 were very evident in social self-evaluations, but not academic ones.

“This pattern is consistent with the enormous importance that most children entering adolescence place on their peer relationships and social status, compared to the relatively diminished value often associated with academics during this transition.”

Absence in autism

In youth with autism spectrum disorders, this specialized response in ventral medial prefrontal cortex is missing, she adds, citing a paper she co-authored in the February 2013 issue of the Journal of Autism and Developmental Disorders and a complementary study led by Michael V. Lombardo, University of Cambridge, in the February 2010 issue of the journal Brain.

The absence of this typical effect, Pfeifer says, might be related to the challenges these individuals often face in both self-understanding and social relations.

The National Institutes of Health funded the research, as did the Santa Fe Institute Consortium, Brain Mapping Medical Research Organization, Brain Mapping Support Foundation, Pierson-Lovelace Foundation, Ahmanson Foundation, Tamkin Foundation, Jennifer Jones-Simon Foundation, Capital Group Companies Charitable Foundation, Robson Family, William M. and Linda R. Dietel Philanthropic Fund at the Northern Piedmont Community Foundation, Northstar Fund, and the NIH National Center for Research Resources.

Co-authors of the new study contributed from University of Oregon, VU University Amsterdam, Vnaderbilt University, University of California, Los Angeles, Ahmanson-Lovelance Brain Mapping Center, and UCLA Center for Culture, Brain, & Development.

Source: University of Oregon

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  1. Liliana Garcia Arroyo

    Very good research design, longitudinal studies are usually superior to transversal reseach designs. No non human animals sacrificed. That’s one of its biggest contributions. Also it is non invasive. I wonder what the children were told before being submitted to the MRIs and whether this made them more socially conscious and thus added a confounding variable into the MRIs readings. Is there any info as to their socioeconomic status? Thanks.

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