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Salt adds to stomach bug’s cancer risk

VANDERBILT (US) — Combining a high-salt diet with a type of H. pylori infection can increase the risk of gastric cancer, according to new research with gerbils.

Infection with the stomach-dwelling bacterium Helicobacter pylori, particularly strains expressing the oncoprotein CagA , is a strong risk factor for gastric cancer.

Timothy Cover, professor of medicine at Vanderbilt University, and colleagues previously showed that high salt, which is also associated with gastric cancer risk, increased H. pylori expression of CagA in vitro.

Now, in studies led by postdoctoral fellow Jennifer Gaddy, the researchers have analyzed the effect of a high-salt diet on H. pylori-induced gastric cancer in a gerbil model.

They report in Infection and Immunity that gerbils infected with CagA-positive strains of H. pylori and fed a high-salt diet had more severe gastric inflammation and a higher rate of cancer compared to gerbils fed a regular diet.

Gerbils infected with CagA-negative strains did not develop cancer, regardless of diet. Infected animals on the high-salt diet had increased CagA expression, consistent with in vitro results.

The findings indicate that a high-salt diet potentiates H. pylori’s carcinogenic effects and suggest that lowering dietary salt may reduce the risk of H. pylori-associated gastric cancer in high-risk populations.

The National Institute of Health and the Department of Veterans Affairs supported the research.

Source: Vanderbilt University

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  1. Steve in DeLand

    Thanks for sharing this information, but I do have an question for you. I remember reading about some study last year in which the stomach-dwelling bacterium h. pylori played a very important role. However, I can’t recall what it was. It is unfortunate, because I believe it would have been worth mentioning. Do you happen to know anything that could be related to this.

  2. Jonathon Rempel

    It would be good to know whether it is “table salt” or “sea salt” (slightly unhelpful names to two very differently metabolizing substances) that is making the difference here with cancer. Perhaps both, or perhaps just one…?

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