Protein in skin T cells helps nix flu virus
U. MELBOURNE (AUS) — Scientists have found a new protein that protects against viral infections, including influenza.
As influenza spreads through the northern hemisphere winter, researchers at the University of Melbourne believe they have a new clue as to why some people fight infections better than others.
They have been investigating the “defensive devices” contained within the T-cells that are located on exposed body surfaces such as skin and mucosal surfaces to ward off infection.
T-cells detect cells infected with viruses and kill them before the virus can reproduce within the infected cell and spread to other cells.
As reported in Nature Immunology, the researchers found these cells contain the protein IFITM3 and this makes them more resistant to viral infections such as influenza.
“If we learn how to increase the number and longevity of T-cells expressing IFITM3, this could lead to improved vaccines that promote the generation of more resistant T-cells able to provide the greatest protection, for longer,” says Professor Jose Villadangos.
“We are currently trying to understand why some T-cells and not others express this protective molecule,” explains study author Linda Wakim.
“Probably they encounter some form of chemical signal (a cytokine, or a surface molecule) in the tissues where they lodge, which induces the expression of IFITM3. If we identify these chemical cues, we may be able to include them in future vaccines.”
Source: University of Melbourne
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