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Protein hints at downside of pear-shape body

UC DAVIS (US) — Conventional wisdom says people with apple-shaped figures face more health risks, but that may be a myth.

People who are “apple-shaped”—with fat more concentrated around the abdomen—have long been considered more at risk than those who are “pear-shaped” and carry weight more in the buttocks, hips, and thighs.

The study, published in The Journal of Clinical Endocrinology and Metabolism, finds that fat stored in the buttock area—also known as gluteal adipose tissue—secretes abnormal levels of chemerin and omentin-1, proteins that can lead to inflammation and a prediabetic condition know as insulin resistance in individuals with early metabolic syndrome.

Metabolic syndrome refers to a group of risk factors that occur together, doubling the risk for heart disease and increasing the risk for diabetes at least five-fold. Risk factors include having a large waistline, low levels of high-density lipoproteins (HDL), or “good” cholesterol, high blood pressure, as well as high fasting blood sugar (insulin resistance), and high triglyceride levels.

According to the Centers for Disease Control and Prevention, metabolic syndrome affects 35 percent of American adults over age 20.

“Fat in the abdomen has long been considered the most detrimental to health, and gluteal fat was thought to protect against diabetes, heart disease, and metabolic syndrome,” says Ishwarlal Jialal, lead author of the study and a professor of pathology and laboratory medicine and of internal medicine at University of California, Davis.

“But our research helps to dispel the myth that gluteal fat is ‘innocent.’ It also suggests that abnormal protein levels may be an early indicator to identify those at risk for developing metabolic syndrome.”

The team found that in individuals with early metabolic syndrome, gluteal fat secreted elevated levels of chemerin and low levels of omentin-1—proteins that correlate with other factors known to increase the risk for heart disease and diabetes.

High chemerin levels, for example, correlated with high blood pressure, elevated levels of C-reactive protein (a sign of inflammation) and triglycerides, insulin resistance, and low levels of HDL cholesterol. Low omentin-1 levels correlated with high levels of triglycerides and blood glucose levels and low levels of HDL cholesterol.

“High chemerin levels correlated with four of the five characteristics of metabolic syndrome and may be a promising biomarker for metabolic syndrome,” says Jialal. “As it’s also an indicator of inflammation and insulin resistance, it could also emerge as part of a biomarker panel to define high-risk obesity states. The good news is that with weight loss, you can reduce chemerin levels along with the risk for metabolic syndrome.”

To conduct the study, Jialal and colleagues recruited 45 patients with early metabolic syndrome—defined as having at least three risk factors for metabolic syndrome including central obesity, hypertension, mild increases in glucose levels not yet in the diabetic range (<126 mg/dl), hyperlipidemia without cardiovascular disease or diabetes.

A control group of 30 subjects had less than two risk factors for metabolic syndrome, with normal glucose and triglyceride levels. Both groups were matched for gender and age.

Complete blood counts, lipid profiles and blood glucose, blood pressure and C-reactive protein levels were measured in all participants. Levels of four proteins secreted by adipose tissue—chemerin, resistin, visfatin, and omentin-1—were also measured in plasma and in subcutaneous fat samples from gluteal tissue.

The researchers found that chemerin levels were increased and omentin-1 levels were decreased in both plasma and gluteal fat of subjects with metabolic syndrome compared to those in the control group. The abnormal levels of these two proteins were also independent of age, body mass index, and waist circumference.

“Future large epidemiological studies should focus on evaluating the role of chemerin as a biomarker for the development of diabetes and cardiovascular disease in metabolic syndrome,” Jialal says.

Other authors of the study contributed from Baylor College of Medicine, UC Davis, University of Texas Southwestern Medical Center, and Vanderbilt University. The American Diabetes Association supported the research.

Source: UC Davis

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