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Neurons show why learning’s tougher as we age

The behavior of inhibitory neurons suggests why learning is easier for the young and more difficult for the old.

The brain is made up of two types of cells—inhibitory and excitatory neurons. Networks of these two kinds of neurons are responsible for processing sensory information like images, sounds, and smells, and for cognitive functioning. About 80 percent of neurons are excitatory. Traditional scientific tools only allowed scientists to study the excitatory neurons.

“We knew from previous studies that excitatory cells propagate information. We also knew that inhibitory neurons played a critical role in setting up heightened plasticity in the young, but ideas about what exactly those cells were doing were controversial,” says Sandra J. Kuhlman, assistant professor of biological sciences at Carnegie Mellon University.

“Since we couldn’t study the cells, we could only hypothesize how they were behaving during critical learning periods.”

The prevailing theory on inhibitory neurons was that, as they mature, they reach an increased level of activity that fosters optimal periods of learning. But as the brain ages into adulthood and the inhibitory neurons continue to mature, they become even stronger to the point where they impede learning.

Newly developed genetic and imaging technologies are now allowing researchers to visualize inhibitory neurons in the brain and record their activity in response to a variety of stimuli.

As a postdoctoral student at University of California, Los Angeles, Kuhlman and her colleagues used these new techniques to record the activity of inhibitory neurons during critical learning periods. They found that, during heightened periods of learning, the inhibitory neurons didn’t fire more as had been expected. They fired much less frequently—up to half as often.

“When you’re young you haven’t experienced much, so your brain needs to be a sponge that soaks up all types of information. It seems that the brain turns off the inhibitory cells in order to allow this to happen,” Kuhlman says.

“As adults we’ve already learned a great number of things, so our brains don’t necessarily need to soak up every piece of information. This doesn’t mean that adults can’t learn, it just means when they learn, their neurons need to behave differently.”

In addition to Kuhlman, researchers from University of California, Irvine, and UCLA contributed to the study, which appears in Nature.

The National Eye Institute, the National Institute of Neurological Disorders and Stroke, and a NARSAD Young Investigator Grant funded the study.

Source: Carnegie Mellon University

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