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Why this multiple sclerosis drug doesn’t work half the time

Researchers say they’ve figured out why a multiple sclerosis drug simply doesn’t work for up to half of patients.

The drug, called interferon-beta, can prevent flare-ups, but has unpleasant side effects and is expensive.

A new study in mice points to biological mechanisms that can lead to a form of MS that doesn’t respond to the drug. Researchers were able to identify new drug candidates that might help MS patients when interferon-beta treatment fails.

“The study shows a really clear molecular mechanism that may explain why some people do not respond to interferon-beta treatment,” says Mari Shinohara, an associate professor of immunology at Duke University and a senior author of the study in Nature Neuroscience. “We’ve found what makes a difference in the response.”

In multiple sclerosis, the body’s immune system mistakenly goes on offense against the nervous system, eating away at the protective coating that wraps around neurons’ long, signal-carrying arms. Without this wrapping, neural signals get jammed and don’t always make it where they need to go, resulting in a vast array of neurological symptoms.

Vary from person to person

Researchers are still sorting out the biological mechanisms that lead to the neural damage of MS, making it tricky to find effective treatments. To add to the challenge, evidence is mounting that the mechanisms could vary from patient to patient, depending on the exact mix of genetic factors and environmental stimuli that led to their disease.

In a 2012 mouse study, Shinohara’s team found that interferon-beta works by inhibiting a giant immune protein complex called the NLRP3 inflammasome. The NLRP3 complex appears to play a key role in triggering the faulty immune responses that make MS patients sick. However, in the same study, they also found that some mice got sick even without this inflammasome—and in these mice, the interferon-beta treatment was completely ineffective.

How ‘tattoo therapy’ might treat multiple sclerosis

In the current study, the team wanted to figure out how this second form of the disease was triggered.

“We knew the second pathway bypassed the NLRP3 inflammasome,” Shinohara says. “So the question became, what is actually involved?”

They found that two specific receptors, called CXCR2 and LTBR, were central to the development of the disease in the mice who did not respond to interferon-beta. And they found that treating the mice with a molecule that blocks these receptors improved their symptoms.

“We found that, depending on which type of disease the mice had, we could choose the appropriate treatment,” Shinohara says.

Pain, inconvenience, and cost

To see if the CXCR2 and LTBR receptors might also play a role in human MS, the team used data gathered as a part of the Murdock-MS study in Kannapolis, North Carolina, to compare the genetic profiles of MS patients who responded to interferon-beta treatment with those who didn’t.

“We identified individuals who were not responsive to the interferon-beta treatment, and looked at their CXCR2 and LTBR relative gene expression levels,” says Simon Gregory, a professor of medicine and molecular genetics and microbiology at Duke and a coauthor of the paper. “We found them to be up-regulated,” meaning they were producing more of the receptors, he says.

These results have the researchers hopeful that targeting the CXCR2 and LTBR receptors might prove a successful treatment in human MS patients. They also plan to explore whether screening for elevated expression of the CXCR2 and LTBR genes might help doctors identify ahead of time which patients are likely to benefit from interferon-beta treatment and which won’t.

“Now these patients have to go through all the pain, inconvenience, and cost of interferon-beta treatment, only to be told that it doesn’t work for them,” Shinohara says. “So it’s a big problem, and it would be really nice if we could tell upfront which treatment works.”

The National Multiple Sclerosis Society and National Institutes of Health supported the study.

Source: Duke University

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