MRI: Quantum computing meets medicine
U. PITTSBURGH (US) — A new study advances toward nanoscale MRI instruments that could study the properties of specific molecules in a noninvasive way.
The research, at the interface of quantum measurement and nanotechnology, suggests that quantum computing may have applications in areas outside of pure electronics.
“Think of this like a typical medical procedure—a magnetic resonance imaging (MRI)—but on single molecules or groups of molecules inside cells instead of the entire body.
“Traditional MRI techniques don’t work well with such small volumes, so an instrument must be built to accommodate such high-precision work,” says Gurudev Dutt, assistant professor of physics and astronomy at the University of Pittsburgh.
However, a significant challenge arose for researchers working on the problem of building such an instrument: How does one measure a magnetic field accurately using the resonance of the single electrons within the diamond crystal?
Resonance is defined as an object’s tendency to oscillate with higher energy at a particular frequency, and occurs naturally all around us: for example, with musical instruments, children on swings, and pendulum clocks.
Resonances are particularly powerful because they allow physicists to make sensitive measurements of quantities like force, mass, and electric and magnetic fields, Dutt says. “But they also restrict the maximum field that one can measure accurately.”
In magnetic imaging, this means that physicists can only detect a narrow range of fields from molecules near the sensor’s resonant frequency, making the imaging process more difficult.
“It can be done,” says Dutt, “but it requires very sophisticated image processing and other techniques to understand what one is imaging. Essentially, one must use software to fix the limitations of hardware, and the scans take longer and are harder to interpret.”
Dutt—working with postdoctoral researcher Ummal Momeen and PhD student Naufer Nusran—has used quantum computing methods to circumvent the hardware limitation to view the entire magnetic field.
By extending the field, researchers have improved the ratio between maximum detectable field strength and field precision by a factor of 10 compared to the standard technique used previously.
Published in the journal Nature Nanotechnology, puts them one step closer toward a future nanoscale MRI instrument that could study properties of molecules, materials, and cells in a noninvasive way, displaying where atoms are located without destroying them; current methods employed for this kind of study inevitably destroy the samples.
“This would have an immediate impact on our understanding of these molecules, materials, or living cells and potentially allow us to create better technologies,” says Dutt.
These are only the initial results, says Dutt, and he expects further improvements to be made with additional research: “Our work shows that quantum computing methods reach beyond pure electronic technologies and can solve problems that, earlier, seemed to be fundamental roadblocks to making progress with high-precision measurements.”
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