Researchers have discovered a mechanism through which mitochondria, the energy factory of our body’s cells, play a role in preventing cells from dying when the cells are deprived of nutrients.
The finding points to a potential target for next-generation cancer drugs.
Cells in our body grow in size, mass, and numbers through a process governed by a master regulator known as mTOR (Mechanistic Target of Rapamycin).
Nahum Sonenberg, professor of biochemistry at McGill University and a senior author of the new research, discovered years ago that mTOR also controls protein expression in all human cells. In particular, mTOR targets the selective synthesis of proteins destined for the mitochondria, the bacteria-like structures in all our cells that generate the energy needed for cells to grow and divide.
In the new research, Sonenberg and his team show that mTOR also controls the expression of proteins that alter the structure and function of mitochondria—thereby protecting cells from dying.
Their work has implications for cancer therapy, since new drugs that act on mTOR are currently in clinical trials for cancer. While the treatments are effective in arresting the expansion and growth of cancer cells, the cells continue to survive, despite a shortage of nutrients. The new study reveals that mitochondria help keep these cells alive by fusing together and blocking a central point in a cell death pathway, called apoptosis.
This advance offers clues to develop combination therapies that could promote cancer-cell death by reversing the protection offered by mitochondria, the researchers say.
The research appears in Molecular Cell.
Source: McGill University