Health & Medicine - Posted by Matthew Solovey-Penn State on Thursday, October 18, 2012 11:26 - 5 Comments
Weight loss doesn’t improve women’s fertility
PENN STATE (US) — Losing weight improves sexual function in women, but not their fertility, a new study shows.
“Obesity in women has been linked to lack of ovulation and thus infertility,” says Richard Legro, professor of obstetrics and gynecology at Penn State. “Obesity, especially centered in the abdomen, among infertile women seeking pregnancy is also associated with poor response to ovulation induction and with decreased pregnancy rates.”
Because obese women are often told to lose weight prior to conception, researchers looked at changes in reproductive function after gastric bypass surgery. One way to learn more about the effects of obesity on reproduction is to study women after bariatric surgery since a large amount of weight is lost in a relatively short period of time. Each person can be studied while obese and after surgery to detect changes.
Straight from the Source
As reported in the Journal of Clinical Endocrinology and Metabolism, Legro and colleagues followed 29 morbidly obese women—women whose body fat accumulated to the extent that it may have an adverse effect on health—of reproductive age for up to two years after Roux en Y gastric bariatric bypass surgery.
Roux en Y is a procedure that creates a small pouch in the stomach that is directly connected to the midsection of the small intestine, bypassing the rest of the stomach and the upper portion of the small intestine.
Ovulation frequency and quality was determined by collecting daily urine specimens over the course of a menstrual cycle and measuring ovarian hormones. Ovulation rates remained high (more than 90 percent at all time points before surgery and at one, three, six, 12, and 24 months after surgery). The quality of the ovulation also remained unchanged, and there was little effect on the ovarian cycle.
The exception is a notable shortening of eight to nine days of the follicular phase. The follicular phase is the first half of the menstrual cycle, from the end of the previous menstrual flow until the release of the egg (ovulation). Three months after surgery, the phase is six and a half days shorter, and then up to nine days shorter by 24 months post-surgery.
Obesity is associated with longer menstrual cycles, specifically because of an increase in the follicular phase. The reason the phase shortens with weight loss is not yet known.
Sexual function at one year as detected by the Female Sexual Function Index, a self-reporting index of sexual health collected through questionnaires, is most noticeable. This improvement is independent of changes in hormone levels and body composition. Sexual desire and arousal increase the most. Researchers did not track sexual activity or desire to conceive. However, increased sexual desire may have led to increased frequency of sexual activity.
“The effects of weight loss on reproductive function are more modest than we hypothesized. In terms of ovulation, there doesn’t appear to be a window after surgery where fertility is improved,” Legro says.
“The door appears to be open at all times. Other factors may be involved with infertility in obese women, such as diminished sexual desire and thus less intercourse. This study, to our knowledge, is the largest, most comprehensive and longest study of female reproductive function before and after Roux en Y gastric bariatric surgery.”
Researchers from the National Institute for Occupational Safety and Health and the State University of New York Upstate Medical Center contributed to the study, which was funded by the Pennsylvania Department of Health using Tobacco Settlement Funds, a Clinical and Translational Science Award from the National Center for Research Resources, and the National Center for Advancing Translational Sciences, National Institutes of Health.
Source: Penn State